Wikipedia

WT1

WT1 (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[39][40]

WT1
Нинди таксонда бар H. sapiens[d][1][1][1]
Кодлаучы ген WT1[d][1][1][1]
Молекуляр функция sequence-specific DNA binding[d][2][3][4][…], ДНК-связывающий[d][5], DNA-binding transcription factor activity[d][6][7][5], zinc ion binding[d][8][9], DNA-binding transcription activator activity, RNA polymerase II-specific[d][10], C2H2 zinc finger domain binding[d][2], связывание с ионом металла[d][5], связывание с белками плазмы[d][11][12][13][…], RNA binding[d][5], nucleic acid binding[d][5], double-stranded methylated DNA binding[d][8], hemi-methylated DNA-binding[d][8], DNA-binding transcription factor activity, RNA polymerase II-specific[d][14][14][10], DNA-binding transcription factor activity, RNA polymerase II-specific[d][15][15][5][…] һәм DNA-binding transcription activator activity, RNA polymerase II-specific[d][5][16]
Күзәнәк компоненты цитоплазма[5][5], ядерные спеклы[d][5][13][12], нуклеоплазма[d][5][5], ядрышко[d][5], төш[10][10][17][…], цитозоль[d][5], төш[5][5][18][…] һәм төш[19]
Биологик процесс germ cell development[d][5], adrenal cortex formation[d][5], ureteric bud development[d][5], negative regulation of translation[d][20], развитие яичек[d][21], male genitalia development[d][5], ДНК-зависимая регуляция транскрипции[d][6][7][5][…], epithelial cell differentiation[d][5], glomerular basement membrane development[d][22], diaphragm development[d][5], нефрогенез[d][23], regulation of transcription by RNA polymerase II[d][10], posterior mesonephric tubule development[d][5], visceral serous pericardium development[d][24], metanephric epithelium development[d][25], негативная регуляция апоптоза[d][26], glomerulus development[d][24], negative regulation of transcription by RNA polymerase II[d][27], развитие надпочечников[d][24], транскрипция, ДНК-зависимая[d][10], positive regulation of metanephric ureteric bud development[d][5], васкулогенез[d][5], ДНК-зависимая позитивная регуляция транскрипции[d][23][11][12][…], positive regulation of heart growth[d][5], йөрәк үсеше[d][24], negative regulation of female gonad development[d][5], branching involved in ureteric bud morphogenesis[d][24], regulation of animal organ formation[d][5], определение пола[d][28], negative regulation of cell growth[d][29][12], Сплайсинг[d][5], cardiac muscle cell fate commitment[d][5], гистогенез[d][5], positive regulation of apoptotic process[d][20], camera-type eye development[d][5], metanephric S-shaped body morphogenesis[d][24], thorax and anterior abdomen determination[d][5], negative regulation of transcription, DNA-templated[d][30][31][32][…], развитие гонады[d][5], metanephric mesenchyme development[d][5], cellular response to gonadotropin stimulus[d][33], positive regulation of male gonad development[d][5], cellular response to cAMP[d][33], негативная регуляция пролиферации клеток[d][34][35], mesenchymal to epithelial transition[d][5], negative regulation of metanephric glomerular mesangial cell proliferation[d][5], положительная регуляция транскрипции РНК полимеразой II промотор[d][10], transcription by RNA polymerase II[d][10], glomerular visceral epithelial cell differentiation[d][5][36], negative regulation of transcription by RNA polymerase II[d][16][37], regulation of transcription by RNA polymerase II[d][5][36], негативная регуляция пролиферации клеток[d][29][12][36], positive regulation of gene expression[d][16], негативная регуляция апоптоза[d][24][36], положительная регуляция транскрипции РНК полимеразой II промотор[d][16], cellular response to cAMP[d][38][36], cellular response to gonadotropin stimulus[d][38][36], positive regulation of pri-miRNA transcription by RNA polymerase II[d][16], positive regulation of DNA methylation[d][16] һәм ДНК-зависимая регуляция транскрипции[d][19]

Искәрмәләр

үзгәртү
  1. ↑ 1,0 1,1 1,2 1,3 1,4 1,5 UniProt
  2. ↑ 2,0 2,1 HD R., IA D., SL M. et al. The Wilms' tumor suppressor gene WT1 is negatively autoregulated // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1994. — ISSN 0021-9258; 1083-351X; 1067-8816 — PMID:8119964
  3. ↑ Ryan G, Steele-Perkins V, JF M. et al. Repression of Pax-2 by WT1 during normal kidney development // Development: the journal of the Society for International Development / J. Briscoe — The Company of Biologists, 1995. — 9 p. — ISSN 0950-1991; 1477-9129; 0212-2448; 1011-6370; 1461-7072 — PMID:7720589
  4. ↑ Morris J. F., Madden S. L., Tournay O. E. et al. Characterization of the zinc finger protein encoded by the WT1 Wilms' tumor locus // Oncogene — NPG, 1991. — ISSN 0950-9232; 1476-5594 — PMID:1662794
  5. ↑ 5,00 5,01 5,02 5,03 5,04 5,05 5,06 5,07 5,08 5,09 5,10 5,11 5,12 5,13 5,14 5,15 5,16 5,17 5,18 5,19 5,20 5,21 5,22 5,23 5,24 5,25 5,26 5,27 5,28 5,29 5,30 5,31 5,32 5,33 5,34 5,35 5,36 5,37 5,38 5,39 5,40 GOA
  6. ↑ 6,0 6,1 Rauscher FJ 3rd The WT1 Wilms tumor gene product: a developmentally regulated transcription factor in the kidney that functions as a tumor suppressor // FASEB J. — FASEB, 1993. — ISSN 0892-6638; 1530-6860 — doi:10.1096/FASEBJ.7.10.8393820 — PMID:8393820
  7. ↑ 7,0 7,1 Hamilton T. B., Barilla K. C., Romaniuk P. J. High affinity binding sites for the Wilms' tumour suppressor protein WT1 // Nucleic Acids Res. — OUP, University of Oxford, 1995. — ISSN 0305-1048; 1362-4962; 1362-4954 — doi:10.1093/NAR/23.2.277 — PMID:7862533
  8. ↑ 8,0 8,1 8,2 Hashimoto H. Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence // Genes Dev. — Cold Spring Harbor Laboratory Press, 2014. — ISSN 0890-9369; 1549-5477 — doi:10.1101/GAD.250746.114 — PMID:25258363
  9. ↑ Ladbury J. E. Why zinc fingers prefer zinc: ligand-field symmetry and the hidden thermodynamics of metal ion selectivity // Biochemistry / A. Schepartz — ACS, 2004. — ISSN 0006-2960; 1520-4995; 1943-295X — doi:10.1021/BI0491999 — PMID:15518539
  10. ↑ 10,0 10,1 10,2 10,3 10,4 10,5 10,6 10,7 GOA
  11. ↑ 11,0 11,1 Liu Y. PINCH1 is transcriptional regulator in podocytes that interacts with WT1 and represses podocalyxin expression, PINCH1 Is Transcriptional Regulator in Podocytes That Interacts with WT1 and Represses Podocalyxin Expression // PLOS ONE / PLOS ONE Editors — PLoS, 2011. — ISSN 1932-6203 — doi:10.1371/JOURNAL.PONE.0017048 — PMID:21390327
  12. ↑ 12,0 12,1 12,2 12,3 12,4 C. Englert Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70 // Genes Dev. — Cold Spring Harbor Laboratory Press, 1998. — ISSN 0890-9369; 1549-5477 — doi:10.1101/GAD.12.8.1108 — PMID:9553041
  13. ↑ 13,0 13,1 Markus M. A., Heinrich B., Raitskin O. et al. WT1 interacts with the splicing protein RBM4 and regulates its ability to modulate alternative splicing in vivo // Exp. Cell. Res. — Academic Press, Elsevier BV, 2006. — ISSN 0014-4827; 1090-2422 — doi:10.1016/J.YEXCR.2006.07.008 — PMID:16934801
  14. ↑ 14,0 14,1 Vaquerizas J. M., Teichmann S., Kummerfeld S. K. A census of human transcription factors: function, expression and evolution // Nature reviews. Genetics — United Kingdom: NPG, 2009. — ISSN 1471-0056; 1471-0064 — doi:10.1038/NRG2538 — PMID:19274049
  15. ↑ 15,0 15,1 Vaquerizas J. M., Teichmann S., Kummerfeld S. K. A census of human transcription factors: function, expression and evolution // Nature reviews. Genetics — United Kingdom: NPG, 2009. — ISSN 1471-0056; 1471-0064 — doi:10.1038/NRG2538 — PMID:19274049
  16. ↑ 16,0 16,1 16,2 16,3 16,4 16,5 Dallosso A. R., Li Y., Roberts S. G. et al. Control of epigenetic states by WT1 via regulation of de novo DNA methyltransferase 3A // Human Molecular Genetics — OUP, 2012. — ISSN 0964-6906; 1460-2083 — doi:10.1093/HMG/DDS403 — PMID:23042785
  17. ↑ M Bachmann Nuclear localization of the protein encoded by the Wilms' tumor gene WT1 in embryonic and adult tissues // Development: the journal of the Society for International Development / J. Briscoe — The Company of Biologists, 1993. — ISSN 0950-1991; 1477-9129; 0212-2448; 1011-6370; 1461-7072 — PMID:8306891
  18. ↑ Englert C. WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis // EMBO J. — NPG, 1995. — ISSN 0261-4189; 1460-2075 — doi:10.1002/J.1460-2075.1995.TB00148.X — PMID:7588596
  19. ↑ 19,0 19,1 GOA
  20. ↑ 20,0 20,1 Englert C. WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis // EMBO J. — NPG, 1995. — ISSN 0261-4189; 1460-2075 — doi:10.1002/J.1460-2075.1995.TB00148.X — PMID:7588596
  21. ↑ S Bhattacharya Developmental changes in human fetal testicular cell numbers and messenger ribonucleic acid levels during the second trimester // J. Clin. Endocrinol. Metab. / R. Paul Robertson — Endocrine Society, 2007. — ISSN 0021-972X; 1945-7197; 0096-7173; 0368-1610 — doi:10.1210/JC.2007-1690 — PMID:17848411
  22. ↑ Sebire N. J. Membranoproliferative glomerulonephritis associated with a mutation in Wilms' tumour suppressor gene 1 // Pediatric Nephrology — Springer Science+Business Media, 2009. — ISSN 0931-041X; 1432-198X — doi:10.1007/S00467-009-1135-8 — PMID:19205749
  23. ↑ 23,0 23,1 Schedl A., Gubler M. WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis // Human Molecular Genetics — OUP, 2002. — ISSN 0964-6906; 1460-2083 — doi:10.1093/HMG/11.6.651 — PMID:11912180
  24. ↑ 24,0 24,1 24,2 24,3 24,4 24,5 24,6 AW M., McInnes L, Kreidberg J et al. YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis // Development: the journal of the Society for International Development / J. Briscoe — The Company of Biologists, 1999. — 13 p. — ISSN 0950-1991; 1477-9129; 0212-2448; 1011-6370; 1461-7072 — PMID:10101119
  25. ↑ Eccles M. R., K Yun, Reeve A. E. et al. Comparative in situ hybridization analysis of PAX2, PAX8, and WT1 gene transcription in human fetal kidney and Wilms' tumors // Am. J. Pathol. — Elsevier BV, 1995. — ISSN 0002-9440; 1525-2191; 0097-3599 — PMID:7856737
  26. ↑ AW M., McInnes L, Kreidberg J et al. YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis // Development: the journal of the Society for International Development / J. Briscoe — The Company of Biologists, 1999. — 13 p. — ISSN 0950-1991; 1477-9129; 0212-2448; 1011-6370; 1461-7072 — PMID:10101119
  27. ↑ Hewitt S. M., S. Hamada, McDonnell T. J. et al. Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1 // Cancer Res. / G. C. Prendergast — American Association for Cancer Research, 1995. — ISSN 0008-5472; 1538-7445 — PMID:7585606
  28. ↑ R Shimamura, Fraizer G. C., J Trapman et al. The Wilms' tumor gene WT1 can regulate genes involved in sex determination and differentiation: SRY, Müllerian-inhibiting substance, and the androgen receptor // Clin. Cancer Res. / K. Flaherty — American Association for Cancer Research, 1997. — ISSN 1078-0432; 1557-3265 — PMID:9815658
  29. ↑ 29,0 29,1 Guan L. S., M Rauchman, Wang Z. Y. Induction of Rb-associated protein (RbAp46) by Wilms' tumor suppressor WT1 mediates growth inhibition // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1998. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.273.42.27047 — PMID:9765217
  30. ↑ Roberts S. G. Dynamic interaction between WT1 and BASP1 in transcriptional regulation during differentiation // Nucleic Acids Res. — OUP, University of Oxford, 2008. — ISSN 0305-1048; 1362-4962; 1362-4954 — doi:10.1093/NAR/GKN955 — PMID:19050011
  31. ↑ Bonthron D. T. Human platelet-derived growth factor A chain is transcriptionally repressed by the Wilms tumor suppressor WT1 // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum — [Washington, etc.], USA: National Academy of Sciences [etc.], 1992. — ISSN 0027-8424; 1091-6490 — doi:10.1073/PNAS.89.22.10984 — PMID:1332065
  32. ↑ Royer-Pokora B., Charalambous M., Ward A. BASP1 is a transcriptional cosuppressor for the Wilms' tumor suppressor protein WT1 // Mol. Cell. Biol. — ASM, 2004. — ISSN 0270-7306; 1098-5549; 1067-8824 — doi:10.1128/MCB.24.2.537-549.2004 — PMID:14701728
  33. ↑ 33,0 33,1 Ferretti E., Arturi F., Tell G. et al. Expression, regulation, and function of paired-box gene 8 in the human placenta and placental cancer cell lines // Endocrinology / T. K. Woodruff — Los Angeles, Calif: Endocrine Society, OUP, 2005. — ISSN 0013-7227; 1945-7170 — doi:10.1210/EN.2005-0084 — PMID:15961562
  34. ↑ C. Englert Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70 // Genes Dev. — Cold Spring Harbor Laboratory Press, 1998. — ISSN 0890-9369; 1549-5477 — doi:10.1101/GAD.12.8.1108 — PMID:9553041
  35. ↑ Guan L. S., M Rauchman, Wang Z. Y. Induction of Rb-associated protein (RbAp46) by Wilms' tumor suppressor WT1 mediates growth inhibition // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1998. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.273.42.27047 — PMID:9765217
  36. ↑ 36,0 36,1 36,2 36,3 36,4 36,5 Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform. — OUP, 2011. — ISSN 1467-5463; 1477-4054 — doi:10.1093/BIB/BBR042 — PMID:21873635
  37. ↑ Hewitt S. M., S. Hamada, McDonnell T. J. et al. Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1 // Cancer Res. / G. C. Prendergast — American Association for Cancer Research, 1995. — ISSN 0008-5472; 1538-7445 — PMID:7585606
  38. ↑ 38,0 38,1 Ferretti E., Arturi F., Tell G. et al. Expression, regulation, and function of paired-box gene 8 in the human placenta and placental cancer cell lines // Endocrinology / T. K. Woodruff — Los Angeles, Calif: Endocrine Society, OUP, 2005. — ISSN 0013-7227; 1945-7170 — doi:10.1210/EN.2005-0084 — PMID:15961562
  39. ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланды. 18 сентябрь, 2017 тикшерелгән.
  40. ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар

үзгәртү
  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)


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