Wikipedia

SMURF1

SMURF1 (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[23][24]

SMURF1
Нинди таксонда бар H. sapiens[d][1]
Кодлаучы ген SMURF1[d][1]
Молекуляр функция R-SMAD binding[d][2], I-SMAD binding[d][3][2], activin binding[d][4], связывание с белками плазмы[d][5][6][7][…], phospholipid binding[d][7], трансферазная активность[d][8], ubiquitin-protein transferase activity[d][8][9][6], ubiquitin protein ligase activity[d][10][10][11][…] һәм ubiquitin protein ligase activity[d][8][8][3][…]
Күзәнәк компоненты цитоплазма[10][12][11][…], цитозоль[d][8], мембрана[d][8], күзәнәк мембранасы[d][8][3], нуклеоплазма[d][8], аксон[d][8], soma[d][8], митохондрия[7], экзосома[d][13], цитоплазма[8][5][3][…] һәм экзосома[d][14]
Биологик процесс дифференцировка клеток[d][8][9], engulfment of target by autophagosome[d][7], ectoderm development[d][9], protein polyubiquitination[d][15], BMP signaling pathway[d][8][5], receptor catabolic process[d][3], ubiquitin-dependent SMAD protein catabolic process[d][11][16], negative regulation of ossification[d][8], protein localization to cell surface[d][3], protein targeting to vacuole involved in autophagy[d][7], positive regulation of ubiquitin-dependent protein catabolic process[d][17], protein ubiquitination[d][10][10][16], protein export from nucleus[d][2], positive regulation of dendrite extension[d][18], proteasome-mediated ubiquitin-dependent protein catabolic process[d][16], negative regulation of transforming growth factor beta receptor signaling pathway[d][3][2], transforming growth factor beta receptor signaling pathway[d][8], Wnt signaling pathway, planar cell polarity pathway[d][8], parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization[d][8], substrate localization to autophagosome[d][7], ubiquitin-dependent protein catabolic process[d][10], negative regulation of BMP signaling pathway[d][19][20], protein localization to plasma membrane[d][7], protein polyubiquitination[d][6][21], ubiquitin-dependent protein catabolic process[d][8][9][6][…], protein ubiquitination[d][8][8][2][…], negative regulation of BMP signaling pathway[d][9][22][21], ubiquitin-dependent SMAD protein catabolic process[d][3][2][21], proteasome-mediated ubiquitin-dependent protein catabolic process[d][2][21] һәм positive regulation of protein catabolic process[d][21]

Искәрмәләр

үзгәртү
  1. ↑ 1,0 1,1 UniProt
  2. ↑ 2,0 2,1 2,2 2,3 2,4 2,5 2,6 T Ebisawa, M Fukuchi, G Murakami et al. Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2001. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.C100008200 — PMID:11278251
  3. ↑ 3,0 3,1 3,2 3,3 3,4 3,5 3,6 3,7 Suzuki C., Murakami G., Fukuchi M. et al. Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2002. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M201901200 — PMID:12151385
  4. ↑ T Yamaguchi, A Kurisaki, N Yamakawa et al. FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor // J. Mol. Endocrinol. — Bioscientifica, 2006. — ISSN 0952-5041; 1479-6813 — doi:10.1677/JME.1.01966 — PMID:16720724
  5. ↑ 5,0 5,1 5,2 Cui Y., He S., Xing C. et al. SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1 // EMBO J. — NPG, 2011. — ISSN 0261-4189; 1460-2075 — doi:10.1038/EMBOJ.2011.155 — PMID:21572392
  6. ↑ 6,0 6,1 6,2 6,3 Li S., Lu K., Wang J. et al. Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation // Mol. Cell. Biochem. — Springer Science+Business Media, 2010. — ISSN 0300-8177; 1573-4919; 0013-9424 — doi:10.1007/S11010-009-0315-Y — PMID:19937093
  7. ↑ 7,0 7,1 7,2 7,3 7,4 7,5 7,6 Levine B., Zhang Y. E., Forst C. V. et al. Image-based genome-wide siRNA screen identifies selective autophagy factors // Nature / M. Skipper — NPG, Springer Science+Business Media, 2011. — ISSN 1476-4687; 0028-0836 — doi:10.1038/NATURE10546 — PMID:22020285
  8. ↑ 8,00 8,01 8,02 8,03 8,04 8,05 8,06 8,07 8,08 8,09 8,10 8,11 8,12 8,13 8,14 8,15 8,16 8,17 8,18 8,19 GOA
  9. ↑ 9,0 9,1 9,2 9,3 9,4 H Zhu, P Kavsak, S Abdollah et al. A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation // Nature / M. Skipper — NPG, Springer Science+Business Media, 1999. — ISSN 1476-4687; 0028-0836 — doi:10.1038/23293 — PMID:10458166
  10. ↑ 10,0 10,1 10,2 10,3 10,4 10,5 GOA
  11. ↑ 11,0 11,1 11,2 Suzuki C., Murakami G., Fukuchi M. et al. Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2002. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M201901200 — PMID:12151385
  12. ↑ Cui Y., He S., Xing C. et al. SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1 // EMBO J. — NPG, 2011. — ISSN 0261-4189; 1460-2075 — doi:10.1038/EMBOJ.2011.155 — PMID:21572392
  13. ↑ Pisitkun T., Tchapyjnikov D., Knepper M. A. Large-scale proteomics and phosphoproteomics of urinary exosomes // Journal of the American Society of Nephrology / J. Briggs — American Society of Nephrology, 2008. — ISSN 1046-6673; 1533-3450 — doi:10.1681/ASN.2008040406 — PMID:19056867
  14. ↑ Pisitkun T., Tchapyjnikov D., Knepper M. A. Large-scale proteomics and phosphoproteomics of urinary exosomes // Journal of the American Society of Nephrology / J. Briggs — American Society of Nephrology, 2008. — ISSN 1046-6673; 1533-3450 — doi:10.1681/ASN.2008040406 — PMID:19056867
  15. ↑ Li S., Lu K., Wang J. et al. Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation // Mol. Cell. Biochem. — Springer Science+Business Media, 2010. — ISSN 0300-8177; 1573-4919; 0013-9424 — doi:10.1007/S11010-009-0315-Y — PMID:19937093
  16. ↑ 16,0 16,1 16,2 T Ebisawa, M Fukuchi, G Murakami et al. Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2001. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.C100008200 — PMID:11278251
  17. ↑ Guo X., Shen S., Song S. et al. The E3 ligase Smurf1 regulates Wolfram syndrome protein stability at the endoplasmic reticulum // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2011. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M111.225615 — PMID:21454619
  18. ↑ Yoo J. C., Lim T. y., Park J. S. et al. SYT14L, especially its C2 domain, is involved in regulating melanocyte differentiation // Journal of Dermatological Science — Elsevier BV, 2013. — ISSN 0923-1811; 1873-569X — doi:10.1016/J.JDERMSCI.2013.07.010 — PMID:23999003
  19. ↑ H Zhu, P Kavsak, S Abdollah et al. A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation // Nature / M. Skipper — NPG, Springer Science+Business Media, 1999. — ISSN 1476-4687; 0028-0836 — doi:10.1038/23293 — PMID:10458166
  20. ↑ Rothman A., Morrell N. W., Lawrie A. et al. MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension // J. Clin. Invest. / R. S. Ahima — American Society for Clinical Investigation, 2016. — ISSN 0021-9738; 1558-8238 — doi:10.1172/JCI83361 — PMID:27214554
  21. ↑ 21,0 21,1 21,2 21,3 21,4 Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform. — OUP, 2011. — ISSN 1467-5463; 1477-4054 — doi:10.1093/BIB/BBR042 — PMID:21873635
  22. ↑ Rothman A., Morrell N. W., Lawrie A. et al. MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension // J. Clin. Invest. / R. S. Ahima — American Society for Clinical Investigation, 2016. — ISSN 0021-9738; 1558-8238 — doi:10.1172/JCI83361 — PMID:27214554
  23. ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланды. 18 сентябрь, 2017 тикшерелгән.
  24. ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар

үзгәртү
  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)


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