Wikipedia

RAD51

RAD51 (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[33][34]

RAD51
Нинди таксонда бар H. sapiens[d][1]
Кодлаучы ген RAD51[d][1]
Молекуляр функция нуклеотид-связывающий[d][2][2], ДНК-связывающий[d][2][2], ATP-dependent activity, acting on DNA[d][3], DNA strand exchange activity[d][2][4], DNA polymerase binding[d][5], protein C-terminus binding[d][6], связывание с белками плазмы[d][7][8][9][…], four-way junction DNA binding[d][3], связывание похожих белков[d][9][10][11][…], endodeoxyribonuclease activity[d][3], АТФ-связанные[d][2][2][12], single-stranded DNA binding[d][13][3][14], double-stranded DNA binding[d][13][3][14], single-stranded DNA helicase activity[d][15][16][17], chromatin binding[d][18], double-stranded DNA binding[d][15][2][16][…], single-stranded DNA binding[d][15][2][16][…], ATP-dependent activity, acting on DNA[d][2][4] һәм enzyme binding[d][18]
Күзәнәк компоненты цитоплазма[2][15][19][…], site of double-strand break[d][20], PML body[d][21], цитоскелет[d][2], нуклеоплазма[d][2], центр организации микротрубочек[d][2], ядерная хромосома[d][22], митохондриальный матрикс[d][2], ядрышко[d][2], митохондрия[2][23], perinuclear region of cytoplasm[d][2][24], хроматин[d][19], төш[2][2][15][…], цитозоль[d][2], protein-containing complex[d][8], condensed chromosome[d][2], condensed nuclear chromosome[d][3], lateral element[d][25], condensed nuclear chromosome[d][2][4] һәм Хромосома[2]
Биологик процесс strand invasion[d][4], mitotic recombination-dependent replication fork processing[d][2], reciprocal meiotic recombination[d][26], DNA recombination[d][16][2], regulation of double-strand break repair via homologous recombination[d][22], процесс метаболизма ДНК[d][2], positive regulation of DNA ligation[d][17], cellular response to camptothecin[d][27], double-strand break repair via homologous recombination[d][28][15][27][…], cellular response to ionizing radiation[d][22][27], mitotic recombination[d][26], protein homooligomerization[d][11], репарация ДНК[d][29][2][2], DNA unwinding involved in DNA replication[d][16], cellular response to DNA damage stimulus[d][15][2][27][…], interstrand cross-link repair[d][30], DNA recombinase assembly[d][13], negative regulation of G0 to G1 transition[d][2], telomere maintenance via recombination[d][31], telomere maintenance via telomere lengthening[d][31], replication fork processing[d][32][19], мейоз[d][2], chromosome organization involved in meiotic cell cycle[d][4], DNA recombinase assembly[d][15][4], mitotic recombination[d][29][4] һәм reciprocal meiotic recombination[d][29][4]
Изображение Gene Atlas

Искәрмәләр

үзгәртү
  1. ↑ 1,0 1,1 UniProt
  2. ↑ 2,00 2,01 2,02 2,03 2,04 2,05 2,06 2,07 2,08 2,09 2,10 2,11 2,12 2,13 2,14 2,15 2,16 2,17 2,18 2,19 2,20 2,21 2,22 2,23 2,24 2,25 2,26 2,27 2,28 2,29 2,30 2,31 GOA
  3. ↑ 3,0 3,1 3,2 3,3 3,4 3,5 GOA
  4. ↑ 4,0 4,1 4,2 4,3 4,4 4,5 4,6 4,7 Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform. — OUP, 2011. — ISSN 1467-5463; 1477-4054 — doi:10.1093/BIB/BBR042 — PMID:21873635
  5. ↑ Moldovan G., Madhavan M. V., Mirchandani K. D. et al. DNA polymerase POLN participates in cross-link repair and homologous recombination // Mol. Cell. Biol. — ASM, 2010. — ISSN 0270-7306; 1098-5549; 1067-8824 — doi:10.1128/MCB.01124-09 — PMID:19995904
  6. ↑ Davies O. R. Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats // Nat. Struct. Mol. Biol. — USA: NPG, 2007. — ISSN 1545-9993; 1545-9985 — doi:10.1038/NSMB1251 — PMID:17515903
  7. ↑ Yuan Z. M., Y. Huang, T. Ishiko et al. Regulation of Rad51 function by c-Abl in response to DNA damage, Regulation of Rad51 Function by c-Abl in Response to DNA Damage // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1998. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.273.7.3799 — PMID:9461559
  8. ↑ 8,0 8,1 Kovalenko O. V., Wiese C., Schild D. RAD51AP2, a novel vertebrate- and meiotic-specific protein, shares a conserved RAD51-interacting C-terminal domain with RAD51AP1/PIR51. // Nucleic Acids Res. — OUP, University of Oxford, 2006. — ISSN 0305-1048; 1362-4962; 1362-4954 — doi:10.1093/NAR/GKL665 — PMID:16990250
  9. ↑ 9,0 9,1 Kovalenko O. V., Golub E. I., P. Bray-Ward et al. A novel nucleic acid-binding protein that interacts with human rad51 recombinase // Nucleic Acids Res. — OUP, University of Oxford, 1997. — ISSN 0305-1048; 1362-4962; 1362-4954 — doi:10.1093/NAR/25.24.4946 — PMID:9396801
  10. ↑ Dosanjh M. K., Z. Shen Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes // Nucleic Acids Res. — OUP, University of Oxford, 1998. — ISSN 0305-1048; 1362-4962; 1362-4954 — doi:10.1093/NAR/26.5.1179 — PMID:9469824
  11. ↑ 11,0 11,1 Blundell T. L. Insights into DNA recombination from the structure of a RAD51-BRCA2 complex // Nature / M. Skipper — NPG, Springer Science+Business Media, 2002. — ISSN 1476-4687; 0028-0836 — doi:10.1038/NATURE01230 — PMID:12442171
  12. ↑ Benthem J. v., Wesoly J., Galjart N. Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosis // Mol. Cell. Biol. — ASM, 2006. — ISSN 0270-7306; 1098-5549; 1067-8824 — doi:10.1128/MCB.26.3.976-989.2006 — PMID:16428451
  13. ↑ 13,0 13,1 13,2 Joenje H., Meijers-Heijboer H., Dunnen J. d. et al. A novel Fanconi anaemia subtype associated with a dominant-negative mutation in RAD51 // Nat. Commun. / J. D. Heber — NPG, 2015. — ISSN 2041-1723 — doi:10.1038/NCOMMS9829 — PMID:26681308
  14. ↑ 14,0 14,1 Benson F. E., West S. C. Purification and characterization of the human Rad51 protein, an analogue of E. coli RecA // EMBO J. — NPG, 1994. — ISSN 0261-4189; 1460-2075 — doi:10.1002/J.1460-2075.1994.TB06914.X — PMID:7988572
  15. ↑ 15,0 15,1 15,2 15,3 15,4 15,5 15,6 15,7 Joenje H., Meijers-Heijboer H., Dunnen J. d. et al. A novel Fanconi anaemia subtype associated with a dominant-negative mutation in RAD51 // Nat. Commun. / J. D. Heber — NPG, 2015. — ISSN 2041-1723 — doi:10.1038/NCOMMS9829 — PMID:26681308
  16. ↑ 16,0 16,1 16,2 16,3 16,4 Benson F. E., West S. C. Purification and characterization of the human Rad51 protein, an analogue of E. coli RecA // EMBO J. — NPG, 1994. — ISSN 0261-4189; 1460-2075 — doi:10.1002/J.1460-2075.1994.TB06914.X — PMID:7988572
  17. ↑ 17,0 17,1 Baumann P., Benson F. E., West S. C. Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro // Cell — Cell Press, Elsevier BV, 1996. — ISSN 0092-8674; 1097-4172 — doi:10.1016/S0092-8674(00)81394-X — PMID:8929543
  18. ↑ 18,0 18,1 Long D. T., Gambus A., Dutta A. et al. The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination // Mol. Cell. Biol. — ASM, 2013. — ISSN 0270-7306; 1098-5549; 1067-8824 — doi:10.1128/MCB.01503-12 — PMID:23401855
  19. ↑ 19,0 19,1 19,2 Beli P., Hanada K. FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51 // Nat. Commun. / J. D. Heber — NPG, 2015. — ISSN 2041-1723 — doi:10.1038/NCOMMS6931 — PMID:25585578
  20. ↑ Huggins D., Jeyasekharan A. D. PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum — [Washington, etc.], USA: National Academy of Sciences [etc.], 2014. — ISSN 0027-8424; 1091-6490 — doi:10.1073/PNAS.1317585111 — PMID:24550317
  21. ↑ O Bischof, Kim S. H., J Irving et al. Regulation and localization of the Bloom syndrome protein in response to DNA damage // J. Cell Biol. / J. Nunnari — Rockefeller University Press, 2001. — ISSN 0021-9525; 1540-8140 — doi:10.1083/JCB.153.2.367 — PMID:11309417
  22. ↑ 22,0 22,1 22,2 Yuan J., Chen J. FIGNL1-containing protein complex is required for efficient homologous recombination repair // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum — [Washington, etc.], USA: National Academy of Sciences [etc.], 2013. — ISSN 0027-8424; 1091-6490 — doi:10.1073/PNAS.1220662110 — PMID:23754376
  23. ↑ Sage J. M., Gildemeister O. S., Knight K. L. Discovery of a novel function for human Rad51: maintenance of the mitochondrial genome // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2010. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M109.099846 — PMID:20413593
  24. ↑ Bennett B. T., Knight K. L. Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51 // J. Cell. Biochem. — Wiley, 2005. — ISSN 0730-2312; 1097-4644; 0733-1959 — doi:10.1002/JCB.20640 — PMID:16215984
  25. ↑ Couch F. J. Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells // Mol. Cell — Cell Press, Elsevier BV, 1998. — ISSN 1097-2765; 1097-4164 — doi:10.1016/S1097-2765(00)80276-2 — PMID:9774970
  26. ↑ 26,0 26,1 A Shinohara, H Ogawa, Y Matsuda et al. Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA // Nature Genetics / M. Axton, T. Faial — NPG, 1993. — ISSN 1061-4036; 1546-1718 — doi:10.1038/NG0793-239 — PMID:8358431
  27. ↑ 27,0 27,1 27,2 27,3 Wan L., Han J., Liu T. et al. Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum — [Washington, etc.], USA: National Academy of Sciences [etc.], 2013. — ISSN 0027-8424; 1091-6490 — doi:10.1073/PNAS.1220921110 — PMID:23509288
  28. ↑ Lio Y., Mazin A. V., Kowalczykowski S. C. et al. Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2003. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M211038200 — PMID:12427746
  29. ↑ 29,0 29,1 29,2 A Shinohara, H Ogawa, Y Matsuda et al. Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA // Nature Genetics / M. Axton, T. Faial — NPG, 1993. — ISSN 1061-4036; 1546-1718 — doi:10.1038/NG0793-239 — PMID:8358431
  30. ↑ Smogorzewska A., Wang A. T., Zierhut H. et al. A Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous Recombination // Mol. Cell — Cell Press, Elsevier BV, 2015. — ISSN 1097-2765; 1097-4164 — doi:10.1016/J.MOLCEL.2015.07.009 — PMID:26253028
  31. ↑ 31,0 31,1 Carlos A. R., Blasco M. A., Benitez J. et al. BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping // Nat. Struct. Mol. Biol. — USA: NPG, 2010. — ISSN 1545-9993; 1545-9985 — doi:10.1038/NSMB.1943 — PMID:21076401
  32. ↑ Vijg J. RAD51 mutants cause replication defects and chromosomal instability // Mol. Cell. Biol. — ASM, 2012. — ISSN 0270-7306; 1098-5549; 1067-8824 — doi:10.1128/MCB.00406-12 — PMID:22778135
  33. ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланды. 18 сентябрь, 2017 тикшерелгән.
  34. ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар

үзгәртү
  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)


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