Wikipedia

PAX8

PAX8 (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[17][18]

PAX8
Нинди таксонда бар H. sapiens[d][1]
Кодлаучы ген PAX8[d][1]
Молекуляр функция ДНК-связывающий[d][2][3][3][…], sequence-specific DNA binding[d][3], DNA-binding transcription factor activity[d][4][5][2], DNA-binding transcription activator activity, RNA polymerase II-specific[d][6][3], RNA polymerase II cis-regulatory region sequence-specific DNA binding[d][6], thyroid-stimulating hormone receptor activity[d][2], связывание с белками плазмы[d][7][8], RNA polymerase II core promoter sequence-specific DNA binding[d][9], DNA-binding transcription factor activity, RNA polymerase II-specific[d][10][10][3] һәм RNA polymerase II cis-regulatory region sequence-specific DNA binding[d][3][5]
Күзәнәк компоненты нуклеоплазма[d][3][3][3] һәм төш[3][3][5][…]
Биологик процесс regulation of apoptotic process[d][3][3], pronephros development[d][3][3], regulation of metanephric nephron tubule epithelial cell differentiation[d][3][3], дифференцировка клеток[d][3][3], mesonephric tubule development[d][3], positive regulation of branching involved in ureteric bud morphogenesis[d][3][3], kidney epithelium development[d][3], ДНК-зависимая регуляция транскрипции[d][3][3], positive regulation of metanephric DCT cell differentiation[d][3][3], negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis[d][3][3], negative regulation of apoptotic process involved in metanephric collecting duct development[d][3][3], нефрогенез[d][11], pronephric field specification[d][3][3], positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis[d][3][3], морфогенез анатомической структуры[d][2], metanephric epithelium development[d][12], mesenchymal to epithelial transition involved in metanephros morphogenesis[d][13], transcription by RNA polymerase II[d][6], regulation of thyroid-stimulating hormone secretion[d][14], транскрипция, ДНК-зависимая[d][3][2], otic vesicle development[d][11], metanephric distal convoluted tubule development[d][3][3], negative regulation of mesenchymal cell apoptotic process involved in metanephros development[d][3][3], mesonephros development[d][3][3], ДНК-зависимая позитивная регуляция транскрипции[d][3][3][5][…], metanephric nephron tubule formation[d][3][3], развитие многоклеточного организма[d][3], үзәк нерв системасы үсеше[d][11][3], metanephric comma-shaped body morphogenesis[d][15], branching involved in ureteric bud morphogenesis[d][15], развитие щитовидной железы[d][2][15][11][…], positive regulation of thyroid hormone generation[d][14][3], negative regulation of apoptotic process involved in metanephric nephron tubule development[d][3][3], S-shaped body morphogenesis[d][3], inner ear morphogenesis[d][3][3], развитие мочеполовой системы[d][3][3], sulfur compound metabolic process[d][3], metanephric S-shaped body morphogenesis[d][15], metanephros development[d][3], cellular response to gonadotropin stimulus[d][16], положительная регуляция транскрипции РНК полимеразой II промотор[d][3][5], thyroid-stimulating hormone signaling pathway[d][3], negative regulation of cardiac muscle cell apoptotic process[d][3] һәм ventricular septum development[d][3]

Искәрмәләр

үзгәртү
  1. ↑ 1,0 1,1 UniProt
  2. ↑ 2,0 2,1 2,2 2,3 2,4 2,5 Macchia P. E., C Missero, M Busslinger PAX8 mutations associated with congenital hypothyroidism caused by thyroid dysgenesis // Nature Genetics / M. Axton, T. Faial — NPG, 1998. — ISSN 1061-4036; 1546-1718 — doi:10.1038/NG0598-83 — PMID:9590296
  3. ↑ 3,00 3,01 3,02 3,03 3,04 3,05 3,06 3,07 3,08 3,09 3,10 3,11 3,12 3,13 3,14 3,15 3,16 3,17 3,18 3,19 3,20 3,21 3,22 3,23 3,24 3,25 3,26 3,27 3,28 3,29 3,30 3,31 3,32 3,33 3,34 3,35 3,36 3,37 3,38 3,39 3,40 3,41 3,42 3,43 3,44 3,45 3,46 3,47 3,48 3,49 3,50 3,51 3,52 3,53 3,54 3,55 3,56 3,57 3,58 3,59 3,60 3,61 GOA
  4. ↑ G Tell Structural defects of a Pax8 mutant that give rise to congenital hypothyroidism // Biochem. J. — London [etc.]: Portland Press, 1999. — 5 p. — ISSN 0264-6021; 1470-8728 — doi:10.1042/BJ3410089 — PMID:10377248
  5. ↑ 5,0 5,1 5,2 5,3 5,4 Fraizer G. C., R Shimamura, X Zhang et al. PAX 8 regulates human WT1 transcription through a novel DNA binding site // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1997. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.272.49.30678 — PMID:9388203
  6. ↑ 6,0 6,1 6,2 GOA
  7. ↑ Palma T. D., D'Andrea B., Liguori G. L. et al. TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation // Exp. Cell. Res. — Academic Press, Elsevier BV, 2009. — ISSN 0014-4827; 1090-2422 — doi:10.1016/J.YEXCR.2008.10.016 — PMID:19010321
  8. ↑ Tomita M. A comprehensive resource of interacting protein regions for refining human transcription factor networks // PLOS ONE / PLOS ONE Editors — PLoS, 2010. — ISSN 1932-6203 — doi:10.1371/JOURNAL.PONE.0009289 — PMID:20195357
  9. ↑ Fraizer G. C., R Shimamura, X Zhang et al. PAX 8 regulates human WT1 transcription through a novel DNA binding site // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1997. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.272.49.30678 — PMID:9388203
  10. ↑ 10,0 10,1 Vaquerizas J. M., Teichmann S., Kummerfeld S. K. A census of human transcription factors: function, expression and evolution // Nature reviews. Genetics — United Kingdom: NPG, 2009. — ISSN 1471-0056; 1471-0064 — doi:10.1038/NRG2538 — PMID:19274049
  11. ↑ 11,0 11,1 11,2 11,3 Attié-Bitach T., Vekemans M., Etchevers H. PAX8, TITF1, and FOXE1 gene expression patterns during human development: new insights into human thyroid development and thyroid dysgenesis-associated malformations // J. Clin. Endocrinol. Metab. / R. Paul Robertson — Endocrine Society, 2005. — ISSN 0021-972X; 1945-7197; 0096-7173; 0368-1610 — doi:10.1210/JC.2004-1358 — PMID:15494458
  12. ↑ Eccles M. R., K Yun, Reeve A. E. et al. Comparative in situ hybridization analysis of PAX2, PAX8, and WT1 gene transcription in human fetal kidney and Wilms' tumors // Am. J. Pathol. — Elsevier BV, 1995. — ISSN 0002-9440; 1525-2191; 0097-3599 — PMID:7856737
  13. ↑ M Dehbi, J Pelletier PAX8-mediated activation of the wt1 tumor suppressor gene // EMBO J. — NPG, 1996. — ISSN 0261-4189; 1460-2075 — doi:10.1002/J.1460-2075.1996.TB00804.X — PMID:8861958
  14. ↑ 14,0 14,1 Costagliola S., Vassart G. Characterization of a novel loss of function mutation of PAX8 in a familial case of congenital hypothyroidism with in-place, normal-sized thyroid // J. Clin. Endocrinol. Metab. / R. Paul Robertson — Endocrine Society, 2004. — ISSN 0021-972X; 1945-7197; 0096-7173; 0368-1610 — doi:10.1210/JC.2004-0166 — PMID:15356023
  15. ↑ 15,0 15,1 15,2 15,3 A. Poleev, H. Fickenscher, S. Mundlos et al. PAX8, a human paired box gene: isolation and expression in developing thyroid, kidney and Wilms' tumors // Development: the journal of the Society for International Development / J. Briscoe — The Company of Biologists, 1992. — ISSN 0950-1991; 1477-9129; 0212-2448; 1011-6370; 1461-7072 — doi:10.1242/DEV.116.3.611 — PMID:1337742
  16. ↑ Ferretti E., Arturi F., Tell G. et al. Expression, regulation, and function of paired-box gene 8 in the human placenta and placental cancer cell lines // Endocrinology / T. K. Woodruff — Los Angeles, Calif: Endocrine Society, OUP, 2005. — ISSN 0013-7227; 1945-7170 — doi:10.1210/EN.2005-0084 — PMID:15961562
  17. ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланды. 18 сентябрь, 2017 тикшерелгән.
  18. ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар

үзгәртү
  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)


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