Wikipedia

METTL3

METTL3 (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[34][35]

METTL3
Нинди таксонда бар H. sapiens[d][1]
Кодирующий ген METTL3[d][1]
Молекулярная функция methyltransferase activity[d][2], трансферазная активность[d][2], RNA binding[d][2], RNA methyltransferase activity[d][3][4][5][…], mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity[d][6][7][8][…], mRNA binding[d][9][10], S-adenosyl-L-methionine binding[d][9][10], protein heterodimerization activity[d][9][10], связывание с белками плазмы[d][11][12][13][…], mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity[d][14][6][7][…], mRNA (N6-adenosine)-methyltransferase activity[d][15][16][17][…], mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity[d][18][19] һәм mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity[d][2]
Күзәнәк компоненты RNA N6-methyladenosine methyltransferase complex[d][20][21][22][…], нуклеоплазма[d][2], ядерные спеклы[d][18][23], төш[18][18][20][…], цитоплазма[2], төш[2][2][24][…], ядерные спеклы[d][2][25][26] һәм RNA N6-methyladenosine methyltransferase complex[d][27][11][5][…]
Биологический процесс ритмический процесс[d][2], mRNA processing[d][2], positive regulation of cap-independent translational initiation[d][28], stem cell population maintenance[d][2], Метилирование[d][2], mRNA methylation[d][16][29][30][…], mRNA destabilization[d][2], циркадный ритм[d][2], primary miRNA processing[d][3], adenosine to inosine editing[d][2], RNA methylation[d][7][18], mRNA splicing, via spliceosome[d][18][31][32], mRNA catabolic process[d][2], forebrain radial glial cell differentiation[d][2], cellular response to UV[d][17], gliogenesis[d][2], regulation of T cell differentiation[d][2], negative regulation of Notch signaling pathway[d][2], regulation of meiotic cell cycle[d][2], endothelial to hematopoietic transition[d][2], regulation of hematopoietic stem cell differentiation[d][2], cellular response to DNA damage stimulus[d][2][17], Сперматогенез[d][2][2], дифференцировка клеток[d][2], dosage compensation by inactivation of X chromosome[d][5], mRNA splicing, via spliceosome[d][2][29][33][…], RNA methylation[d][15][2][26] һәм процесс метаболизма РНК[d][2]

Искәрмәләр үзгәртү

  1. ↑ 1,0 1,1 UniProt
  2. ↑ 2,00 2,01 2,02 2,03 2,04 2,05 2,06 2,07 2,08 2,09 2,10 2,11 2,12 2,13 2,14 2,15 2,16 2,17 2,18 2,19 2,20 2,21 2,22 2,23 2,24 2,25 2,26 2,27 2,28 2,29 2,30 GOA
  3. ↑ 3,0 3,1 Goodarzi H., Halberg N. N6-methyladenosine marks primary microRNAs for processing // Nature / M. Skipper — NPG, Springer Science+Business Media, 2015. — ISSN 1476-4687; 0028-0836 — doi:10.1038/NATURE14281 — PMID:25799998
  4. ↑ Schöller E., Weichmann F., Treiber T. et al. Interactions, localization and phosphorylation of the m6A generating METTL3-METTL14-WTAP complex. // RNA — Cold Spring Harbor Laboratory Press, 2018. — ISSN 1355-8382; 1469-9001 — doi:10.1261/RNA.064063.117 — PMID:29348140
  5. ↑ 5,0 5,1 5,2 Patil D. P., Jaffrey S. R., Guttman M. m(6)A RNA methylation promotes XIST-mediated transcriptional repression // Nature / M. Skipper — NPG, Springer Science+Business Media, 2016. — ISSN 1476-4687; 0028-0836 — doi:10.1038/NATURE19342 — PMID:27602518
  6. ↑ 6,0 6,1 Jambhekar A. RNA m6A methylation regulates the ultraviolet-induced DNA damage response // Nature / M. Skipper — NPG, Springer Science+Business Media, 2017. — ISSN 1476-4687; 0028-0836 — doi:10.1038/NATURE21671 — PMID:28297716
  7. ↑ 7,0 7,1 7,2 Bokar J. A., Shambaugh M. E., D Polayes et al. Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase // RNA — Cold Spring Harbor Laboratory Press, 1997. — ISSN 1355-8382; 1469-9001 — PMID:9409616
  8. ↑ Schwartz S., Jacob-Hirsch J., Dominissini D. et al. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq // Nature / M. Skipper — NPG, Springer Science+Business Media, 2012. — ISSN 1476-4687; 0028-0836 — doi:10.1038/NATURE11112 — PMID:22575960
  9. ↑ 9,0 9,1 9,2 Liu Z., Zou T. Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex // Nature / M. Skipper — NPG, Springer Science+Business Media, 2016. — ISSN 1476-4687; 0028-0836 — doi:10.1038/NATURE18298 — PMID:27281194
  10. ↑ 10,0 10,1 10,2 Wang P., Doxtader K. A., Nam Y. Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases // Mol. Cell — Cell Press, Elsevier BV, 2016. — ISSN 1097-2765; 1097-4164 — doi:10.1016/J.MOLCEL.2016.05.041 — PMID:27373337
  11. ↑ 11,0 11,1 Luo G., He C., Liu J. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation // Cell discovery — NPG, 2018. — ISSN 2056-5968 — doi:10.1038/S41421-018-0019-0 — PMID:29507755
  12. ↑ Mansfeld J., Hein M. Y., Hyman A. A. et al. A human interactome in three quantitative dimensions organized by stoichiometries and abundances // Cell — Cell Press, Elsevier BV, 2015. — ISSN 0092-8674; 1097-4172 — doi:10.1016/J.CELL.2015.09.053 — PMID:26496610
  13. ↑ Wang Y., Li Y., Toth J. I. et al. N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells // Nat. Cell Biol. — NPG, 2014. — ISSN 1465-7392; 1476-4679 — doi:10.1038/NCB2902 — PMID:24394384
  14. ↑ Parisien M. N6-methyladenosine-dependent regulation of messenger RNA stability // Nature / M. Skipper — NPG, Springer Science+Business Media, 2014. — ISSN 1476-4687; 0028-0836 — doi:10.1038/NATURE12730 — PMID:24284625
  15. ↑ 15,0 15,1 Bokar J. A., Shambaugh M. E., D Polayes et al. Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase // RNA — Cold Spring Harbor Laboratory Press, 1997. — ISSN 1355-8382; 1469-9001 — PMID:9409616
  16. ↑ 16,0 16,1 Schwartz S., Jacob-Hirsch J., Dominissini D. et al. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq // Nature / M. Skipper — NPG, Springer Science+Business Media, 2012. — ISSN 1476-4687; 0028-0836 — doi:10.1038/NATURE11112 — PMID:22575960
  17. ↑ 17,0 17,1 17,2 Jambhekar A. RNA m6A methylation regulates the ultraviolet-induced DNA damage response // Nature / M. Skipper — NPG, Springer Science+Business Media, 2017. — ISSN 1476-4687; 0028-0836 — doi:10.1038/NATURE21671 — PMID:28297716
  18. ↑ 18,0 18,1 18,2 18,3 18,4 18,5 GOA
  19. ↑ Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform. — OUP, 2011. — ISSN 1467-5463; 1477-4054 — doi:10.1093/BIB/BBR042 — PMID:21873635
  20. ↑ 20,0 20,1 Liu J., Yue Y., Han D. et al. A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation // Nature Chemical Biology — NPG, 2014. — ISSN 1552-4450; 1552-4469 — doi:10.1038/NCHEMBIO.1432 — PMID:24316715
  21. ↑ Patil D. P., Jaffrey S. R., Guttman M. m(6)A RNA methylation promotes XIST-mediated transcriptional repression // Nature / M. Skipper — NPG, Springer Science+Business Media, 2016. — ISSN 1476-4687; 0028-0836 — doi:10.1038/NATURE19342 — PMID:27602518
  22. ↑ Luo G., He C., Liu J. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation // Cell discovery — NPG, 2018. — ISSN 2056-5968 — doi:10.1038/S41421-018-0019-0 — PMID:29507755
  23. ↑ Dahal U., Liu F. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase // Cell Res. — NPG, Springer Nature, Springer Science+Business Media, 2014. — ISSN 1001-0602; 1748-7838 — doi:10.1038/CR.2014.3 — PMID:24407421
  24. ↑ Jaffrey S. R. Dynamic m(6)A mRNA methylation directs translational control of heat shock response // Nature / M. Skipper — NPG, Springer Science+Business Media, 2015. — ISSN 1476-4687; 0028-0836 — doi:10.1038/NATURE15377 — PMID:26458103
  25. ↑ Dahal U., Liu F. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase // Cell Res. — NPG, Springer Nature, Springer Science+Business Media, 2014. — ISSN 1001-0602; 1748-7838 — doi:10.1038/CR.2014.3 — PMID:24407421
  26. ↑ 26,0 26,1 Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform. — OUP, 2011. — ISSN 1467-5463; 1477-4054 — doi:10.1093/BIB/BBR042 — PMID:21873635
  27. ↑ Jínek M., Sledź P. Structural insights into the molecular mechanism of the m(6)A writer complex // eLife / M. B. Eisen — eLife Sciences Publications Ltd, 2016. — ISSN 2050-084X — doi:10.7554/ELIFE.18434 — PMID:27627798
  28. ↑ Meyer K. D., Patil D. P. 5' UTR m(6)A Promotes Cap-Independent Translation // Cell — Cell Press, Elsevier BV, 2015. — ISSN 0092-8674; 1097-4172 — doi:10.1016/J.CELL.2015.10.012 — PMID:26593424
  29. ↑ 29,0 29,1 Liu N., Parisien M. N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions // Nature / M. Skipper — NPG, Springer Science+Business Media, 2015. — ISSN 1476-4687; 0028-0836 — doi:10.1038/NATURE14234 — PMID:25719671
  30. ↑ Parisien M. N6-methyladenosine-dependent regulation of messenger RNA stability // Nature / M. Skipper — NPG, Springer Science+Business Media, 2014. — ISSN 1476-4687; 0028-0836 — doi:10.1038/NATURE12730 — PMID:24284625
  31. ↑ Liu N., Parisien M. N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions // Nature / M. Skipper — NPG, Springer Science+Business Media, 2015. — ISSN 1476-4687; 0028-0836 — doi:10.1038/NATURE14234 — PMID:25719671
  32. ↑ Goodarzi H. HNRNPA2B1 Is a Mediator of m(6)A-Dependent Nuclear RNA Processing Events // Cell — Cell Press, Elsevier BV, 2015. — ISSN 0092-8674; 1097-4172 — doi:10.1016/J.CELL.2015.08.011 — PMID:26321680
  33. ↑ Goodarzi H. HNRNPA2B1 Is a Mediator of m(6)A-Dependent Nuclear RNA Processing Events // Cell — Cell Press, Elsevier BV, 2015. — ISSN 0092-8674; 1097-4172 — doi:10.1016/J.CELL.2015.08.011 — PMID:26321680
  34. ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланды. 18 сентябрь, 2017 тикшерелгән.
  35. ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар үзгәртү

  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)


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