MAP2 (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[13][14]

MAP2
Нинди таксонда бар H. sapiens[d][1]
Кодирующий ген MAP2[d][1]
Молекулярная функция tubulin binding[d][2], связывание с белками плазмы[d][3], structural molecule activity[d][4], dystroglycan binding[d][5], calmodulin binding[d][2], microtubule binding[d][6][6], microtubule binding[d][7][2][2][…] һәм tau protein binding[d][8]
Күзәнәк компоненты ядрышко[d][2], микротрубочка[d][2], microtubule associated complex[d][4], Цитоскелет[d][2], Цитоплазма[6][6], цитозоль[d][6], дендрит[d][2][2][2], cell projection[d][2], внутренний компонент клетки[d][6], Постсинаптическое уплотнение[d][2], nuclear periphery[d][2], neuron projection[d][2][9], neuronal cell body[d][6], dendritic shaft[d][6], cell body[d][2], CA3 pyramidal cell dendrite[d][2], Цитоплазма[2][2][2], цитозоль[d][2][2], dendrite cytoplasm[d][2], neuronal cell body[d][2][2], axon initial segment[d][2], dendritic shaft[d][2][2], Аксонный холмик[d][2][2], dendritic growth cone[d][2], main axon[d][2], dendritic branch[d][2], basal dendrite[d][2], primary dendrite[d][2], distal dendrite[d][2], apical distal dendrite[d][2], dendritic filopodium[d][2], proximal dendrite[d][2] һәм proximal neuron projection[d][2][2]
Биологический процесс neuron projection development[d][10], microtubule cytoskeleton organization[d][6], microtubule bundle formation[d][2][2], dendrite morphogenesis[d][11], central nervous system neuron development[d][11][2], axonogenesis[d][2], dendrite development[d][6], establishment of cell polarity[d][2], regulation of axonogenesis[d][2], cellular response to organic substance[d][2], microtubule cytoskeleton organization[d][2][2][9], dendrite development[d][7][2], negative regulation of axon extension[d][2][2], regulation of microtubule polymerization[d][12], negative regulation of microtubule polymerization[d][2], neuron projection development[d][11][9], positive regulation of anterograde dense core granule transport[d][2], regulation of organelle transport along microtubule[d][2], positive regulation of anterograde synaptic vesicle transport[d][2] һәм negative regulation of microtubule binding[d][2]

Искәрмәләр үзгәртү

  1. 1,0 1,1 UniProt
  2. 2,00 2,01 2,02 2,03 2,04 2,05 2,06 2,07 2,08 2,09 2,10 2,11 2,12 2,13 2,14 2,15 2,16 2,17 2,18 2,19 2,20 2,21 2,22 2,23 2,24 2,25 2,26 2,27 2,28 2,29 2,30 2,31 2,32 2,33 2,34 2,35 2,36 2,37 2,38 2,39 2,40 2,41 2,42 2,43 2,44 2,45 2,46 2,47 2,48 2,49 2,50 2,51 2,52 2,53 2,54 2,55 2,56 GOA
  3. Tomita M. A comprehensive resource of interacting protein regions for refining human transcription factor networks // PLOS ONE / PLOS ONE EditorsPLoS, 2010. — ISSN 1932-6203doi:10.1371/JOURNAL.PONE.0009289PMID:20195357
  4. 4,0 4,1 B Shafit-Zagardo, N Kalcheva Making sense of the multiple MAP-2 transcripts and their role in the neuron // Mol. Neurobiol.Springer Science+Business Media, 1998. — ISSN 0893-7648; 1559-1182doi:10.1007/BF02740642PMID:9588626
  5. Cerecedo D., Cisneros B., Suárez-Sánchez R. et al. beta-Dystroglycan modulates the interplay between actin and microtubules in human-adhered platelets // Br. J. Haematol.Wiley-Blackwell, 2008. — ISSN 0007-1048; 1365-2141doi:10.1111/J.1365-2141.2008.07048.XPMID:18341635
  6. 6,00 6,01 6,02 6,03 6,04 6,05 6,06 6,07 6,08 6,09 GOA
  7. 7,0 7,1 Atapour N., Hensch T. K., Hirokawa N. Defects in Synaptic Plasticity, Reduced NMDA-Receptor Transport, and Instability of Postsynaptic Density Proteins in Mice Lacking Microtubule-Associated Protein 1A // J. Neurosci. / M. PicciottoSociety for Neuroscience, 2015. — ISSN 0270-6474; 1529-2401doi:10.1523/JNEUROSCI.2671-15.2015PMID:26609151
  8. Guo T., Noble W., Hanger D. P. Roles of tau protein in health and disease // Acta Neuropathol. (Berl)Springer Science+Business Media, 2017. — ISSN 0001-6322; 1432-0533doi:10.1007/S00401-017-1707-9PMID:28386764
  9. 9,0 9,1 9,2 Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform.OUP, 2011. — ISSN 1467-5463; 1477-4054doi:10.1093/BIB/BBR042PMID:21873635
  10. Jovanov-Milošević N. Morphology, molecular phenotypes and distribution of neurons in developing human corpus callosum // Eur. J. Neurosci.Wiley-Blackwell, 2010. — ISSN 0953-816X; 1460-9568doi:10.1111/J.1460-9568.2010.07400.XPMID:20846339
  11. 11,0 11,1 11,2 Jovanov-Milošević N. Morphology, molecular phenotypes and distribution of neurons in developing human corpus callosum // Eur. J. Neurosci.Wiley-Blackwell, 2010. — ISSN 0953-816X; 1460-9568doi:10.1111/J.1460-9568.2010.07400.XPMID:20846339
  12. CX G., Wegiel J, Lidsky T et al. Regulation of phosphorylation of neuronal microtubule-associated proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain. // Brain Res.Elsevier BV, 2000. — ISSN 0006-8993; 1872-6240doi:10.1016/S0006-8993(99)02294-5PMID:10640627
  13. HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланды. 18 сентябрь, 2017 тикшерелгән.
  14. UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар үзгәртү

  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)