LSS (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[17][18]

LSS
Нинди таксонда бар H. sapiens[d][1]
Кодлаучы ген LSS[d][1]
Молекуляр функция изомеразная активность[d][2], intramolecular transferase activity[d][2], lanosterol synthase activity[d][3][4][5][…], lanosterol synthase activity[d][2][6][7][…] һәм beta-amyrin synthase activity[d][2]
Күзәнәк компоненты lipid droplet[d][8][9], endoplasmic reticulum membrane[d][2][2], эндоплазматик челтәр[2], мембрана[d][3][10], lipid droplet[d][11][12][13], мембрана[d][2][14] һәм lipid droplet[d][2][11][12][…]
Биологик процесс regulation of protein stability[d][6], липидный обмен[d][2], steroid biosynthetic process[d][6][2], cholesterol biosynthetic process[d][3][15], regulation of cholesterol biosynthetic process[d][2], cholesterol biosynthetic process[d][2][16][13] һәм triterpenoid biosynthetic process[d][2]

Искәрмәләр

үзгәртү
  1. 1,0 1,1 UniProt
  2. 2,00 2,01 2,02 2,03 2,04 2,05 2,06 2,07 2,08 2,09 2,10 2,11 2,12 2,13 GOA
  3. 3,0 3,1 3,2 GOA
  4. Abagyan R., Wang J., Yan Y. et al. Lanosterol reverses protein aggregation in cataracts // Nature / M. SkipperNPG, Springer Science+Business Media, 2015. — ISSN 1476-4687; 0028-0836doi:10.1038/NATURE14650PMID:26200341
  5. Corey E. J. Molecular cloning of the human gene encoding lanosterol synthase from a liver cDNA library, Molecular-Cloning of the Human Gene Encoding Lanosterol Synthase from a Liver cDNA Library // Biochem. Biophys. Res. Commun.Academic Press, Elsevier BV, 1995. — ISSN 0006-291X; 1090-2104doi:10.1006/BBRC.1995.2110PMID:7639730
  6. 6,0 6,1 6,2 Abagyan R., Wang J., Yan Y. et al. Lanosterol reverses protein aggregation in cataracts // Nature / M. SkipperNPG, Springer Science+Business Media, 2015. — ISSN 1476-4687; 0028-0836doi:10.1038/NATURE14650PMID:26200341
  7. Corey E. J. Molecular cloning of the human gene encoding lanosterol synthase from a liver cDNA library, Molecular-Cloning of the Human Gene Encoding Lanosterol Synthase from a Liver cDNA Library // Biochem. Biophys. Res. Commun.Academic Press, Elsevier BV, 1995. — ISSN 0006-291X; 1090-2104doi:10.1006/BBRC.1995.2110PMID:7639730
  8. Fujimoto Y., Itabe H., Sakai J. et al. Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7 // Biochim. Biophys. ActaElsevier BV, 2004. — 13 p. — ISSN 0006-3002; 1878-2434doi:10.1016/J.BBAMCR.2003.10.018PMID:14741744
  9. Shevchenko A. Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine // J. Biol. Chem. / L. M. GieraschBaltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2011. — ISSN 0021-9258; 1083-351X; 1067-8816doi:10.1074/JBC.M110.202424PMID:21498505
  10. Lippert D. Defining the membrane proteome of NK cells // J. Mass Spectrom.Wiley, 2010. — ISSN 1076-5174; 1096-9888doi:10.1002/JMS.1696PMID:19946888
  11. 11,0 11,1 Shevchenko A. Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine // J. Biol. Chem. / L. M. GieraschBaltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2011. — ISSN 0021-9258; 1083-351X; 1067-8816doi:10.1074/JBC.M110.202424PMID:21498505
  12. 12,0 12,1 Fujimoto Y., Itabe H., Sakai J. et al. Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7 // Biochim. Biophys. ActaElsevier BV, 2004. — 13 p. — ISSN 0006-3002; 1878-2434doi:10.1016/J.BBAMCR.2003.10.018PMID:14741744
  13. 13,0 13,1 Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform.OUP, 2011. — ISSN 1467-5463; 1477-4054doi:10.1093/BIB/BBR042PMID:21873635
  14. Lippert D. Defining the membrane proteome of NK cells // J. Mass Spectrom.Wiley, 2010. — ISSN 1076-5174; 1096-9888doi:10.1002/JMS.1696PMID:19946888
  15. Hegele R. A., Markle J. G., Huff M. W. Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol // J. Biol. Chem. / L. M. GieraschBaltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2007. — ISSN 0021-9258; 1083-351X; 1067-8816doi:10.1074/JBC.M611063200PMID:17186944
  16. Hegele R. A., Markle J. G., Huff M. W. Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol // J. Biol. Chem. / L. M. GieraschBaltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2007. — ISSN 0021-9258; 1083-351X; 1067-8816doi:10.1074/JBC.M611063200PMID:17186944
  17. HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланды. 18 сентябрь, 2017 тикшерелгән.
  18. UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар

үзгәртү
  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)