Wikipedia

GAS6

GAS6 (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[24][25]

GAS6
Нинди таксонда бар H. sapiens[d][1]
Кодлаучы ген GAS6[d][1]
Молекуляр функция связывание с белками плазмы[d][2][3][4], signaling receptor binding[d][5][6], receptor tyrosine kinase binding[d][7], voltage-gated calcium channel activity[d][8], receptor ligand activity[d][9][10], molecular adaptor activity[d][11], phosphatidylserine binding[d][11], связывание с ионом металла[d][9], protein tyrosine kinase activator activity[d][4], calcium ion binding[d][9], cysteine-type endopeptidase inhibitor activity involved in apoptotic process[d][12], protein-macromolecule adaptor activity[d][11] һәм receptor ligand activity[d][9][10][13]
Күзәнәк компоненты endoplasmic reticulum lumen[d][9], цитоплазма[8], Люмен аппарата Гольджи[d][9], platelet alpha granule lumen[d][9], экзосома[d][14][15], күзәнәк тышындагы өлкә[d][9][9][9], внутренний компонент клетки[d][16], күзәнәк тышындагы мохит[d][9][8][17][…] һәм экзосома[d][18]
Биологик процесс positive regulation of natural killer cell differentiation[d][19], apoptotic cell clearance[d][9][11], cellular response to vitamin K[d][6], negative regulation of DNA-binding transcription factor activity[d][20], positive regulation of protein kinase activity[d][5], negative regulation of biomineral tissue development[d][21], negative regulation of tumor necrosis factor-mediated signaling pathway[d][22], cellular response to starvation[d][9], positive regulation of phagocytosis[d][8], позитивная регуляция сигналов от протеинкиназы В[d][9][6][20][…], positive regulation of cytokine-mediated signaling pathway[d][19], positive regulation of gene expression[d][22], dendritic cell differentiation[d][22], neuron migration[d][9], агрегация клеток[d][23], protein kinase B signaling[d][9][4][12], positive regulation of glomerular filtration[d][9][9], B cell chemotaxis[d][17], негативная регуляция апоптоза[d][9][17], positive regulation of ERK1 and ERK2 cascade[d][10], Фагоцитоз[11], regulation of growth[d][9], активация протеинкиназы В[d][9][9], negative regulation of tumor necrosis factor production[d][4][22], platelet degranulation[d][9], viral entry into host cell[d][11], negative regulation of oligodendrocyte apoptotic process[d][12], leukocyte migration[d][9], enzyme linked receptor protein signaling pathway[d][9], positive regulation of protein tyrosine kinase activity[d][4], миграция клеток[d][23], platelet activation[d][23], negative regulation of transcription, DNA-templated[d][20], positive regulation of protein export from nucleus[d][20], регенерация органов[d][9], cellular response to growth factor stimulus[d][9], negative regulation of interferon-gamma production[d][19], macrophage cytokine production[d][9], cellular response to glucose stimulus[d][9][9], hematopoietic stem cell migration to bone marrow[d][17], negative regulation of dendritic cell apoptotic process[d][22], calcium ion transmembrane transport[d][8], cell-substrate adhesion[d][9], negative regulation of interleukin-6 production[d][22], positive regulation of dendritic cell chemotaxis[d][22], signal peptide processing[d][16], viral genome replication[d][11], пролиферация[d][23], positive regulation of fibroblast proliferation[d][5][10], negative regulation of cysteine-type endopeptidase activity involved in apoptotic process[d][12], negative regulation of fibroblast apoptotic process[d][6], positive regulation of peptidyl-serine phosphorylation[d][12], platelet aggregation[d][23], positive regulation of TOR signaling[d][9][9], peptidyl-serine phosphorylation[d][4][20], endoplasmic reticulum to Golgi vesicle-mediated transport[d][9], вирусный процесс[d][9], extracellular matrix assembly[d][9][9], cellular response to interferon-alpha[d][22], фосфорилация белка[d][6], negative regulation of renal albumin absorption[d][9][9], negative regulation of endothelial cell apoptotic process[d][6][3][20], positive regulation of protein phosphorylation[d][9][9][5][…], передача сигнала[d][23][9][5][…], cвёртывание крови[d][9], апоптоз[d][9], посттрансляционная модификация[d][9], protein localization to plasma membrane[d][6], regulation of signaling receptor activity[d][9], apoptotic cell clearance[d][9][11][13] һәм protein kinase B signaling[d][9][4][12][…]

Искәрмәләр

үзгәртү
  1. ↑ 1,0 1,1 UniProt
  2. ↑ C Ekman, J Stenhoff, B Dahlbäck Gas6 is complexed to the soluble tyrosine kinase receptor Axl in human blood // Journal of Thrombosis and Haemostasis — Wiley-Blackwell, 2010. — ISSN 1538-7933; 1538-7836 — doi:10.1111/J.1538-7836.2010.03752.X — PMID:20088931
  3. ↑ 3,0 3,1 Rajotte I., Hasanbasic I., Blostein M. Gas6-mediated signaling is dependent on the engagement of its gamma-carboxyglutamic acid domain with phosphatidylserine // Biochem. Biophys. Res. Commun. — Academic Press, Elsevier BV, 2008. — ISSN 0006-291X; 1090-2104 — doi:10.1016/J.BBRC.2008.08.083 — PMID:18760998
  4. ↑ 4,0 4,1 4,2 4,3 4,4 4,5 4,6 Sola D., Sainaghi P. P. TNF-alpha, IL-6, and IL-1 expression is inhibited by GAS6 in monocytes/macrophages // J. Leukoc. Biol. / L. Montaner — Wiley-Blackwell, 2010. — ISSN 0741-5400; 1938-3673 — doi:10.1189/JLB.0909610 — PMID:20103767
  5. ↑ 5,0 5,1 5,2 5,3 5,4 Varnum B. C., C Young, G Elliott et al. Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6 // Nature / M. Skipper — NPG, Springer Science+Business Media, 1995. — ISSN 1476-4687; 0028-0836 — doi:10.1038/373623A0 — PMID:7854420
  6. ↑ 6,0 6,1 6,2 6,3 6,4 6,5 6,6 I Hasanbasic, I Rajotte, M Blostein The role of gamma-carboxylation in the anti-apoptotic function of gas6 // Journal of Thrombosis and Haemostasis — Wiley-Blackwell, 2005. — ISSN 1538-7933; 1538-7836 — doi:10.1111/J.1538-7836.2005.01662.X — PMID:16359517
  7. ↑ Hammonds R. G. Reevaluation of the roles of protein S and Gas6 as ligands for the receptor tyrosine kinase Rse/Tyro 3, Reevaluation of the roles of protein S and gas6 as ligands for the receptor tyrosine kinase Rse/Tyro 3 // Cell — Cell Press, Elsevier BV, 1995. — ISSN 0092-8674; 1097-4172 — doi:10.1016/0092-8674(95)90424-7 — PMID:7634325
  8. ↑ 8,0 8,1 8,2 8,3 8,4 Karl M. O., Engelmann K. Endogenous Gas6 and Ca2+ -channel activation modulate phagocytosis by retinal pigment epithelium // Cell. Signal. — Elsevier BV, 2008. — 10 p. — ISSN 0898-6568; 1873-3913 — doi:10.1016/J.CELLSIG.2008.02.005 — PMID:18395422
  9. ↑ 9,00 9,01 9,02 9,03 9,04 9,05 9,06 9,07 9,08 9,09 9,10 9,11 9,12 9,13 9,14 9,15 9,16 9,17 9,18 9,19 9,20 9,21 9,22 9,23 9,24 9,25 9,26 9,27 9,28 9,29 9,30 9,31 9,32 9,33 9,34 9,35 9,36 9,37 9,38 9,39 9,40 9,41 9,42 9,43 9,44 9,45 9,46 9,47 GOA
  10. ↑ 10,0 10,1 10,2 10,3 Hafizi S. Vitamin K-dependent Gas6 activates ERK kinase and stimulates growth of cardiac fibroblasts // Biochem. Biophys. Res. Commun. — Academic Press, Elsevier BV, 2004. — ISSN 0006-291X; 1090-2104 — doi:10.1016/J.BBRC.2004.05.070 — PMID:15184064
  11. ↑ 11,0 11,1 11,2 11,3 11,4 11,5 11,6 11,7 Lee B. The soluble serum protein Gas6 bridges virion envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry // Cell Host & Microbe — Cell Press, Elsevier BV, 2011. — ISSN 1931-3128; 1934-6069 — doi:10.1016/J.CHOM.2011.03.012 — PMID:21501828
  12. ↑ 12,0 12,1 12,2 12,3 12,4 12,5 Brosnan C. F. Gas6/Axl signaling activates the phosphatidylinositol 3-kinase/Akt1 survival pathway to protect oligodendrocytes from tumor necrosis factor alpha-induced apoptosis // J. Neurosci. / M. Picciotto — Society for Neuroscience, 2006. — ISSN 0270-6474; 1529-2401 — doi:10.1523/JNEUROSCI.5063-05.2006 — PMID:16723520
  13. ↑ 13,0 13,1 Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform. — OUP, 2011. — ISSN 1467-5463; 1477-4054 — doi:10.1093/BIB/BBR042 — PMID:21873635
  14. ↑ Sinha A., Kislinger T. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine // Proteomics / L. Stimson — Wiley, 2013. — ISSN 1615-9853; 1615-9861 — doi:10.1002/PMIC.201200561 — PMID:23533145
  15. ↑ Farina A., Lane L., Lescuyer P. et al. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine // Journal of Proteomics — Elsevier BV, 2013. — ISSN 1874-3919; 0165-022X — doi:10.1016/J.JPROT.2013.01.012 — PMID:23376485
  16. ↑ 16,0 16,1 GOA
  17. ↑ 17,0 17,1 17,2 17,3 Taichman R. S. GAS6/Mer axis regulates the homing and survival of the E2A/PBX1-positive B-cell precursor acute lymphoblastic leukemia in the bone marrow niche // Exp. Hematol. / C. Eaves — Elsevier BV, 2010. — ISSN 0301-472X; 1873-2399 — doi:10.1016/J.EXPHEM.2009.11.002 — PMID:19922767
  18. ↑ Sinha A., Kislinger T. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine // Proteomics / L. Stimson — Wiley, 2013. — ISSN 1615-9853; 1615-9861 — doi:10.1002/PMIC.201200561 — PMID:23533145
  19. ↑ 19,0 19,1 19,2 Caligiuri M. A. The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development // Blood — American Society of Hematology, Elsevier BV, 2009. — ISSN 0006-4971; 1528-0020 — doi:10.1182/BLOOD-2008-05-157073 — PMID:18840707
  20. ↑ 20,0 20,1 20,2 20,3 20,4 20,5 Ganopolsky J. G., Abid M. R., Aird W. C. et al. GAS6-induced signaling in human endothelial cells is mediated by FOXO1a // Journal of Thrombosis and Haemostasis — Wiley-Blackwell, 2008. — ISSN 1538-7933; 1538-7836 — doi:10.1111/J.1538-7836.2008.03114.X — PMID:18680538
  21. ↑ Son B., Akishita M., Iijima K. et al. Androgen receptor-dependent transactivation of growth arrest-specific gene 6 mediates inhibitory effects of testosterone on vascular calcification // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2010. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M109.055087 — PMID:20048160
  22. ↑ 22,0 22,1 22,2 22,3 22,4 22,5 22,6 22,7 Musso T., Cappello P., Giovarelli M. et al. Survival and migration of human dendritic cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway // J. Immunol. — Baltimore: 2009. — ISSN 0022-1767; 1550-6606 — doi:10.4049/JIMMUNOL.0804384 — PMID:19657094
  23. ↑ 23,0 23,1 23,2 23,3 23,4 23,5 Burnier L. Role of the growth arrest-specific gene 6 (gas6) product in thrombus stabilization // Blood Cells, Molecules and Diseases — Elsevier BV, 2006. — ISSN 1079-9796; 1096-0961 — doi:10.1016/J.BCMD.2005.12.038 — PMID:16564713
  24. ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланды. 18 сентябрь, 2017 тикшерелгән.
  25. ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар

үзгәртү
  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)


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