GAL (ген) (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[18][19]

GAL
Нинди таксонда бар H. sapiens[d][1]
Кодлаучы ген GAL[d][1]
Молекуляр функция hormone activity[d][2][2], galanin receptor activity[d][3], type 1 galanin receptor binding[d][4], type 2 galanin receptor binding[d][4], type 3 galanin receptor binding[d][4], neuropeptide hormone activity[d][5][6], связывание с белками плазмы[d][3][7] һәм neuropeptide hormone activity[d][8][4][9]
Күзәнәк компоненты күзәнәк тышындагы өлкә[d][2][2][2], цитоплазма[2], Гольджи аппараты[2], soma[d][10], secretory granule[d][2][9], күзәнәк тышындагы мохит[d][11] һәм күзәнәк тышындагы мохит[d][12][9]
Биологик процесс негативная регуляция пролиферации клеток[d][2], positive regulation of timing of catagen[d][13], пищевое поведение[d][2], positive regulation of cortisol secretion[d][14], positive regulation of large conductance calcium-activated potassium channel activity[d][15], regulation of glucocorticoid metabolic process[d][2], response to immobilization stress[d][2], insulin secretion[d][16], protein kinase A signaling[d][14], cAMP-mediated signaling[d][14], positive regulation of apoptotic process[d][2], нерв системасы үсеше[d][2], negative regulation of root hair elongation[d][13], response to estrogen[d][2], response to insulin[d][2], положительная регуляция транскрипции РНК полимеразой II промотор[d][4], воспалительная реакция[d][2], negative regulation of lymphocyte proliferation[d][2], neuropeptide signaling pathway[d][17][17], regulation of signaling receptor activity[d][2], G protein-coupled receptor signaling pathway[d][2] һәм neuropeptide signaling pathway[d][2][9]
Изображение Gene Atlas

Искәрмәләр

үзгәртү
  1. 1,0 1,1 UniProt
  2. 2,00 2,01 2,02 2,03 2,04 2,05 2,06 2,07 2,08 2,09 2,10 2,11 2,12 2,13 2,14 2,15 2,16 2,17 2,18 2,19 2,20 GOA
  3. 3,0 3,1 Muhle H., Helbig I., Rudolf G. et al. Galanin pathogenic mutations in temporal lobe epilepsy // Human Molecular GeneticsOUP, 2015. — ISSN 0964-6906; 1460-2083doi:10.1093/HMG/DDV060PMID:25691535
  4. 4,0 4,1 4,2 4,3 4,4 Kim D., Yun S., Son G. H. et al. Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III // Endocrinology / T. K. WoodruffLos Angeles, Calif: Endocrine Society, OUP, 2014. — ISSN 0013-7227; 1945-7170doi:10.1210/EN.2013-2106PMID:24517231
  5. Schmidt W. E., H. Kratzin, K. Eckart et al. Isolation and primary structure of pituitary human galanin, a 30-residue nonamidated neuropeptide // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum[Washington, etc.], USA: National Academy of Sciences [etc.], 1991. — ISSN 0027-8424; 1091-6490doi:10.1073/PNAS.88.24.11435PMID:1722333
  6. Kim D., Yun S., Son G. H. et al. Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III // Endocrinology / T. K. WoodruffLos Angeles, Calif: Endocrine Society, OUP, 2014. — ISSN 0013-7227; 1945-7170doi:10.1210/EN.2013-2106PMID:24517231
  7. Dricot A., Barabási A., Tavernier J. et al. A proteome-scale map of the human interactome network // CellCell Press, Elsevier BV, 2014. — ISSN 0092-8674; 1097-4172doi:10.1016/J.CELL.2014.10.050PMID:25416956
  8. Schmidt W. E., H. Kratzin, K. Eckart et al. Isolation and primary structure of pituitary human galanin, a 30-residue nonamidated neuropeptide // Proc. Natl. Acad. Sci. U.S.A. / M. R. Berenbaum[Washington, etc.], USA: National Academy of Sciences [etc.], 1991. — ISSN 0027-8424; 1091-6490doi:10.1073/PNAS.88.24.11435PMID:1722333
  9. 9,0 9,1 9,2 9,3 Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform.OUP, 2011. — ISSN 1467-5463; 1477-4054doi:10.1093/BIB/BBR042PMID:21873635
  10. I Merchenthaler, G Rotoli, M Peroski et al. Catecholaminergic system innervates galanin-immunoreactive neurons in the human diencephalon // Neuroscience / J. L. GómezElsevier BV, 2013. — ISSN 0306-4522; 1873-7544doi:10.1016/J.NEUROSCIENCE.2013.02.007PMID:23415787
  11. G Ceresini, A Fabbo, M Freddi et al. Concomitant evaluation of plasma galanin and catecholamine levels during a cold pressor test in healthy human male and female subjects // Horm. Res. Paediatr.Karger Publishers, 1997. — ISSN 0301-0163; 1423-0046doi:10.1159/000185533PMID:9402244
  12. G Ceresini, A Fabbo, M Freddi et al. Concomitant evaluation of plasma galanin and catecholamine levels during a cold pressor test in healthy human male and female subjects // Horm. Res. Paediatr.Karger Publishers, 1997. — ISSN 0301-0163; 1423-0046doi:10.1159/000185533PMID:9402244
  13. 13,0 13,1 R Paus, B Kofler The neuropeptide galanin is a novel inhibitor of human hair growth // Br. J. Dermatol.Wiley-Blackwell, 2012. — ISSN 0007-0963; 1365-2133doi:10.1111/J.1365-2133.2012.10890.XPMID:22329353
  14. 14,0 14,1 14,2 Guidolin D., Nussdorfer G. G., Malendowicz L. K. et al. Galanin stimulates cortisol secretion from human adrenocortical cells through the activation of galanin receptor subtype 1 coupled to the adenylate cyclase-dependent signaling cascade // International Journal of Molecular MedicineSpandidos Publishing, 2007. — ISSN 1107-3756; 1791-244XPMID:17982695
  15. Hökfelt T., Xu Z. D. Activation of galanin receptor 2 stimulates large conductance Ca(2+)-dependent K(+) (BK) channels through the IP3 pathway in human embryonic kidney (HEK293) cells // Biochem. Biophys. Res. Commun.Academic Press, Elsevier BV, 2014. — ISSN 0006-291X; 1090-2104doi:10.1016/J.BBRC.2014.02.110PMID:24602615
  16. McKnight G. L., Karlsen A. E., S Kowalyk et al. Sequence of human galanin and its inhibition of glucose-stimulated insulin secretion from RIN cells // DiabetesAmerican Diabetes Association, 1992. — ISSN 0012-1797; 1939-327Xdoi:10.2337/DIAB.41.1.82PMID:1370155
  17. 17,0 17,1 GOA
  18. HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланды. 18 сентябрь, 2017 тикшерелгән.
  19. UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар

үзгәртү
  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)