Wikipedia

FAS (ген)

FAS (ген) (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[33][34]

FAS
Сурәт
Нинди таксонда бар H. sapiens[d][1]
Кодирующий ген Fas-рецептор[d][1]
Молекулярная функция kinase binding[d][2], связывание с белками плазмы[d][3][4][5][…], transmembrane signaling receptor activity[d][6], signal transducer activity[d][7][8], связывание похожих белков[d][2][9][10], tumor necrosis factor-activated receptor activity[d][11], tumor necrosis factor binding[d][11], calmodulin binding[d][6][12] һәм signaling receptor activity[d][13][14]
Күзәнәк компоненты CD95 death-inducing signaling complex[d][11][15], мембрана[d][6][6], внеклеточная область[d][6], поверхность клетки[d][11][16], экзосома[d][17], часть мембраны[d][6], күзәнәк мембраны[d][6][18][6][…], часть клеточной мембраны[d][11], наружная сторона клеточной мембраны[d][11], death-inducing signaling complex[d][19][20], Липидный рафт[d][10], цитозоль[d][14][6], ядерные тельца[d][6], митохондрия[d][11], поверхность клетки[d][21], CD95 death-inducing signaling complex[d][22] һәм экзосома[d][23]
Биологический процесс renal system process[d][11], activation-induced cell death of T cells[d][11], tumor necrosis factor-mediated signaling pathway[d][11], T cell homeostasis[d][11], positive regulation of extrinsic apoptotic signaling pathway in absence of ligand[d][11], cellular response to mechanical stimulus[d][24], Циркадный ритм[d][11], apoptotic signaling pathway[d][11][11], positive regulation of extrinsic apoptotic signaling pathway[d][11], regulation of extrinsic apoptotic signaling pathway via death domain receptors[d][6], activation of cysteine-type endopeptidase activity involved in apoptotic process[d][6], апоптоз[d][25][13][6][…], activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway[d][11], развитие селезёнки[d][11], negative thymic T cell selection[d][11], regulation of lymphocyte differentiation[d][11], necroptotic signaling pathway[d][26][11], motor neuron apoptotic process[d][11], воспалительная реакция[d][11], regulation of myeloid cell differentiation[d][11], protein homooligomerization[d][11], response to toxic substance[d][11], B cell mediated immunity[d][11], neuron apoptotic process[d][11], positive regulation of protein homooligomerization[d][11], cellular response to lithium ion[d][11], positive regulation of lymphocyte apoptotic process[d][11], негативная регуляция апоптоза[d][27][11], иммунный ответ[d][11][11], экспрессия генов[d][11], cellular response to hyperoxia[d][10], negative regulation of B cell activation[d][11], response to glucocorticoid[d][11], extrinsic apoptotic signaling pathway in absence of ligand[d][11], inflammatory cell apoptotic process[d][11], immunoglobulin production[d][11], передача сигнала[d][28][6], hepatocyte apoptotic process[d][11], response to lipopolysaccharide[d][11], extrinsic apoptotic signaling pathway[d][16][11], regulation of apoptotic process[d][6][14], positive regulation of apoptotic process[d][22][18], regulation of cell population proliferation[d][11], negative regulation of extrinsic apoptotic signaling pathway via death domain receptors[d][6], multicellular organism development[d][11], extrinsic apoptotic signaling pathway via death domain receptors[d][11], positive regulation of protein phosphorylation[d][29], regulation of stress-activated MAPK cascade[d][29], cellular response to amino acid starvation[d][29], Fas signaling pathway[d][29], positive regulation of apoptotic signaling pathway[d][29], positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway[d][29], иммунный ответ[d][6], негативная регуляция апоптоза[d][30], protein-containing complex assembly[d][31], apoptotic signaling pathway[d][6], extrinsic apoptotic signaling pathway[d][21] һәм necroptotic signaling pathway[d][32]
Изображение Gene Atlas

Искәрмәләр үзгәртү

  1. ↑ 1,0 1,1 UniProt
  2. ↑ 2,0 2,1 Stanger B. Z., P Leder, Lee T. H. et al. RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death // Cell — Cell Press, Elsevier BV, 1995. — ISSN 0092-8674; 1097-4172 — doi:10.1016/0092-8674(95)90072-1 — PMID:7538908
  3. ↑ Casanova J., Puel A., Rieux-Laucat F. et al. Whole-exome-sequencing-based discovery of human FADD deficiency // Am. J. Hum. Genet. — Cell Press, Elsevier BV, 2010. — ISSN 0002-9297; 1537-6605 — doi:10.1016/J.AJHG.2010.10.028 — PMID:21109225
  4. ↑ Chui Y. A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2004. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M408678200 — PMID:15465831
  5. ↑ Chen T., Lin K., Chen C. et al. Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network // J. Proteome Res. / J. Yates — ACS, 2014. — ISSN 1535-3893; 1535-3907 — doi:10.1021/PR5002737 — PMID:25241761
  6. ↑ 6,00 6,01 6,02 6,03 6,04 6,05 6,06 6,07 6,08 6,09 6,10 6,11 6,12 6,13 6,14 6,15 6,16 6,17 GOA
  7. ↑ Siegel R. M., Frederiksen J. K., Zacharias D. A. et al. Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations // Science / H. Thorp — AAAS, 2000. — ISSN 0036-8075; 1095-9203 — doi:10.1126/SCIENCE.288.5475.2354 — PMID:10875918
  8. ↑ Hueber A. O., M Zörnig, D Lyon et al. Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis // Science / H. Thorp — AAAS, 1997. — ISSN 0036-8075; 1095-9203 — doi:10.1126/SCIENCE.278.5341.1305 — PMID:9360929
  9. ↑ Boldin M. P., Varfolomeev E. E., Z Pancer et al. A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1995. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.270.14.7795 — PMID:7536190
  10. ↑ 10,0 10,1 10,2 Augustine M K Choi Caveolin-1 mediates Fas-BID signaling in hyperoxia-induced apoptosis // Free Radic. Biol. Med. — Elsevier BV, 2011. — ISSN 0891-5849; 1873-4596 — doi:10.1016/J.FREERADBIOMED.2011.02.031 — PMID:21382479
  11. ↑ 11,00 11,01 11,02 11,03 11,04 11,05 11,06 11,07 11,08 11,09 11,10 11,11 11,12 11,13 11,14 11,15 11,16 11,17 11,18 11,19 11,20 11,21 11,22 11,23 11,24 11,25 11,26 11,27 11,28 11,29 11,30 11,31 11,32 11,33 11,34 11,35 11,36 11,37 11,38 11,39 11,40 11,41 11,42 11,43 11,44 11,45 GOA
  12. ↑ Dong Y. Structural insights into the mechanism of calmodulin binding to death receptors // Acta Crystallographica Section D: Biological Crystallography — Wiley-Blackwell, 2014. — ISSN 0907-4449; 1399-0047 — doi:10.1107/S1399004714006919 — PMID:24914971
  13. ↑ 13,0 13,1 M. Pawlita Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1992. — ISSN 0021-9258; 1083-351X; 1067-8816 — PMID:1375228
  14. ↑ 14,0 14,1 14,2 Ruberti G. Three functional soluble forms of the human apoptosis-inducing Fas molecule are produced by alternative splicing // J. Immunol. — Baltimore: 1995. — ISSN 0022-1767; 1550-6606 — PMID:7533181
  15. ↑ Siegel R. M., Raunser S., Robinson C. V. The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations // Nat. Struct. Mol. Biol. — USA: NPG, 2010. — ISSN 1545-9993; 1545-9985 — doi:10.1038/NSMB.1920 — PMID:20935634
  16. ↑ 16,0 16,1 Koncz G., Hancz A., Chakrabandhu K. et al. Vesicles released by activated T cells induce both Fas-mediated RIP-dependent apoptotic and Fas-independent nonapoptotic cell deaths // J. Immunol. — Baltimore: 2012. — ISSN 0022-1767; 1550-6606 — doi:10.4049/JIMMUNOL.1102827 — PMID:22891283
  17. ↑ Buschow S. I., Stoorvogel W., Wauben M. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis // Immunology & Cell Biology — Wiley, 2010. — ISSN 0818-9641; 1440-1711 — doi:10.1038/ICB.2010.64 — PMID:20458337
  18. ↑ 18,0 18,1 Shatnyeva O. M., Kubarenko A. V., Claudia E M Weber et al. Modulation of the CD95-induced apoptosis: the role of CD95 N-glycosylation // PLOS ONE / PLOS ONE Editors — PLoS, 2011. — ISSN 1932-6203 — doi:10.1371/JOURNAL.PONE.0019927 — PMID:21625644
  19. ↑ Berkova Z., Daniluk U. PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo // Blood — American Society of Hematology, Elsevier BV, 2011. — ISSN 0006-4971; 1528-0020 — doi:10.1182/BLOOD-2011-04-349670 — PMID:21803845
  20. ↑ J Tschopp, Valitutti S. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule // Nat. Immunol. — USA: NPG, 2000. — ISSN 1529-2908; 1529-2916 — doi:10.1038/82732 — PMID:11101870
  21. ↑ 21,0 21,1 Koncz G., Hancz A., Chakrabandhu K. et al. Vesicles released by activated T cells induce both Fas-mediated RIP-dependent apoptotic and Fas-independent nonapoptotic cell deaths // J. Immunol. — Baltimore: 2012. — ISSN 0022-1767; 1550-6606 — doi:10.4049/JIMMUNOL.1102827 — PMID:22891283
  22. ↑ 22,0 22,1 Siegel R. M., Raunser S., Robinson C. V. The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations // Nat. Struct. Mol. Biol. — USA: NPG, 2010. — ISSN 1545-9993; 1545-9985 — doi:10.1038/NSMB.1920 — PMID:20935634
  23. ↑ Buschow S. I., Stoorvogel W., Wauben M. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis // Immunology & Cell Biology — Wiley, 2010. — ISSN 0818-9641; 1440-1711 — doi:10.1038/ICB.2010.64 — PMID:20458337
  24. ↑ D'Agostino R. Expression of the Bcl-2 protein BAD promotes prostate cancer growth // PLOS ONE / PLOS ONE Editors — PLoS, 2009. — ISSN 1932-6203 — doi:10.1371/JOURNAL.PONE.0006224 — PMID:19593445
  25. ↑ Ivanov V. N. p38 protects human melanoma cells from UV-induced apoptosis through down-regulation of NF-kappaB activity and Fas expression // Oncogene — NPG, 2000. — ISSN 0950-9232; 1476-5594 — doi:10.1038/SJ.ONC.1203602 — PMID:10871852
  26. ↑ Pope R. M., Temkin V. Inhibition of ADP/ATP exchange in receptor-interacting protein-mediated necrosis // Mol. Cell. Biol. — ASM, 2006. — ISSN 0270-7306; 1098-5549; 1067-8824 — doi:10.1128/MCB.26.6.2215-2225.2006 — PMID:16507998
  27. ↑ J Cheng, T Zhou, C Liu et al. Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule // Science / H. Thorp — AAAS, 1994. — ISSN 0036-8075; 1095-9203 — doi:10.1126/SCIENCE.7510905 — PMID:7510905
  28. ↑ Hueber A. O., M Zörnig, D Lyon et al. Requirement for the CD95 receptor-ligand pathway in c-Myc-induced apoptosis // Science / H. Thorp — AAAS, 1997. — ISSN 0036-8075; 1095-9203 — doi:10.1126/SCIENCE.278.5341.1305 — PMID:9360929
  29. ↑ 29,0 29,1 29,2 29,3 29,4 29,5 Ko Y. G., Kim E. Y., T Kim et al. Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1 // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2001. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M006189200 — PMID:11096076
  30. ↑ J Cheng, T Zhou, C Liu et al. Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule // Science / H. Thorp — AAAS, 1994. — ISSN 0036-8075; 1095-9203 — doi:10.1126/SCIENCE.7510905 — PMID:7510905
  31. ↑ Siegel R. M., Frederiksen J. K., Zacharias D. A. et al. Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations // Science / H. Thorp — AAAS, 2000. — ISSN 0036-8075; 1095-9203 — doi:10.1126/SCIENCE.288.5475.2354 — PMID:10875918
  32. ↑ Pope R. M., Temkin V. Inhibition of ADP/ATP exchange in receptor-interacting protein-mediated necrosis // Mol. Cell. Biol. — ASM, 2006. — ISSN 0270-7306; 1098-5549; 1067-8824 — doi:10.1128/MCB.26.6.2215-2225.2006 — PMID:16507998
  33. ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланды. 18 сентябрь, 2017 тикшерелгән.
  34. ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар үзгәртү

  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)


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