CCL20 (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[19][20]

CCL20
Нинди таксонда бар H. sapiens[d][1]
Кодлаучы ген CCL20[d][1]
Молекуляр функция cytokine activity[d][2][2], связывание с белками плазмы[d][3][4][5], CCR6 chemokine receptor binding[d][2][6][7], chemokine activity[d][8][2][9] һәм CCR chemokine receptor binding[d][9]
Күзәнәк компоненты күзәнәк тышындагы өлкә[d][2][2][2], внутренний компонент клетки[d][10] һәм күзәнәк тышындагы мохит[d][11][2][9]
Биологик процесс monocyte chemotaxis[d][9], positive regulation of T cell migration[d][12], neutrophil chemotaxis[d][9], positive regulation of ERK1 and ERK2 cascade[d][9], positive regulation of GTPase activity[d][9], positive regulation of nitric-oxide synthase biosynthetic process[d][10], defense response to bacterium[d][2], передача сигнала между клетками[d][11], lymphocyte chemotaxis[d][9], Заживление ран[d][10], cellular response to lipoteichoic acid[d][10], cellular response to tumor necrosis factor[d][9], cellular response to organic substance[d][10], chemokine-mediated signaling pathway[d][9], cellular response to interleukin-1[d][9], cellular response to interferon-gamma[d][9], передача сигнала[d][11], иммун җавап[d][13][2], cellular response to lipopolysaccharide[d][10], хемотаксис[d][8][2][2][…], calcium-mediated signaling using intracellular calcium source[d][14], cell chemotaxis[d][15], T cell migration[d][2][2], thymocyte migration[d][2][2], воспалительная реакция[d][16][2][9], antimicrobial humoral immune response mediated by antimicrobial peptide[d][17][18], regulation of signaling receptor activity[d][2], G protein-coupled receptor signaling pathway[d][2][9] һәм cytokine-mediated signaling pathway[d][2]
Изображение Gene Atlas

Искәрмәләр

үзгәртү
  1. 1,0 1,1 UniProt
  2. 2,00 2,01 2,02 2,03 2,04 2,05 2,06 2,07 2,08 2,09 2,10 2,11 2,12 2,13 2,14 2,15 2,16 2,17 2,18 2,19 GOA
  3. Jeang K., Iha H., Ikeda F. et al. Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation // EMBO J.NPG, 2008. — ISSN 0261-4189; 1460-2075doi:10.1038/EMBOJ.2008.5PMID:18239685
  4. Hundelshausen P. V., Grommes J., Weber C. et al. Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation // Sci. Transl. Med.AAAS, 2017. — ISSN 1946-6234; 1946-6242doi:10.1126/SCITRANSLMED.AAH6650PMID:28381538
  5. Shembade N., Harhaj N. S., Liebl D. J. et al. Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling // EMBO J.NPG, 2007. — ISSN 0261-4189; 1460-2075doi:10.1038/SJ.EMBOJ.7601823PMID:17703191
  6. Ai L., Liao F. Mutating the four extracellular cysteines in the chemokine receptor CCR6 reveals their differing roles in receptor trafficking, ligand binding, and signaling // Biochemistry / A. SchepartzACS, 2002. — ISSN 0006-2960; 1520-4995; 1943-295Xdoi:10.1021/BI025855YPMID:12081481
  7. Röhrl J., Yang D., Oppenheim J. J. et al. Specific binding and chemotactic activity of mBD4 and its functional orthologue hBD2 to CCR6-expressing cells // J. Biol. Chem. / L. M. GieraschBaltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2010. — ISSN 0021-9258; 1083-351X; 1067-8816doi:10.1074/JBC.M109.091090PMID:20068036
  8. 8,0 8,1 D Yang, Howard O. M., Q Chen et al. Cutting edge: immature dendritic cells generated from monocytes in the presence of TGF-beta 1 express functional C-C chemokine receptor 6 // J. Immunol.Baltimore: 1999. — ISSN 0022-1767; 1550-6606PMID:10438902
  9. 9,00 9,01 9,02 9,03 9,04 9,05 9,06 9,07 9,08 9,09 9,10 9,11 9,12 9,13 Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform.OUP, 2011. — ISSN 1467-5463; 1477-4054doi:10.1093/BIB/BBR042PMID:21873635
  10. 10,0 10,1 10,2 10,3 10,4 10,5 GOA
  11. 11,0 11,1 11,2 Nomiyama H. Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2 // J. Biol. Chem. / L. M. GieraschBaltimore [etc.]: American Society for Biochemistry and Molecular Biology, 1997. — ISSN 0021-9258; 1083-351X; 1067-8816doi:10.1074/JBC.272.9.5846PMID:9038201
  12. Chiang Y., Lee F. S. CBAP functions as a novel component in chemokine-induced ZAP70-mediated T-cell adhesion and migration // PLOS ONE / PLOS ONE EditorsPLoS, 2013. — ISSN 1932-6203doi:10.1371/JOURNAL.PONE.0061761PMID:23620790
  13. Howard O. M., Chertov O. Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6 // Science / H. ThorpNorthern America: AAAS, 1999. — ISSN 0036-8075; 1095-9203doi:10.1126/SCIENCE.286.5439.525PMID:10521347
  14. Fok E., Chen H., Ng C. Deficient human β-defensin 1 underlies male infertility associated with poor sperm motility and genital tract infection // Sci. Transl. Med.AAAS, 2014. — ISSN 1946-6234; 1946-6242doi:10.1126/SCITRANSLMED.3009071PMID:25122636
  15. Caballero-Campo P., Buffone M. G., Benencia F. et al. A role for the chemokine receptor CCR6 in mammalian sperm motility and chemotaxis // J. Cell. Physio.Wiley, 2014. — ISSN 0021-9541; 1097-4652doi:10.1002/JCP.24418PMID:23765988
  16. R. Hromas, Gray P. W., D. Chantry et al. Cloning and characterization of exodus, a novel beta-chemokine // BloodAmerican Society of Hematology, Elsevier BV, 1997. — ISSN 0006-4971; 1528-0020PMID:9129037
  17. Moser B., Wolf M., Mühlemann K. Potent and broad-spectrum antimicrobial activity of CXCL14 suggests an immediate role in skin infections // J. Immunol.Baltimore: 2009. — ISSN 0022-1767; 1550-6606doi:10.4049/JIMMUNOL.182.1.507PMID:19109182
  18. Yang D., Chen Q., Hoover D. M. et al. Many chemokines including CCL20/MIP-3alpha display antimicrobial activity. // J. Leukoc. Biol. / L. MontanerWiley-Blackwell, 2003. — ISSN 0741-5400; 1938-3673doi:10.1189/JLB.0103024PMID:12949249
  19. HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланды. 18 сентябрь, 2017 тикшерелгән.
  20. UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар

үзгәртү
  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)