Wikipedia

LACRT

LACRT (ингл. ) — аксымы, шул ук исемдәге ген тарафыннан кодлана торган югары молекуляр органик матдә.[24][25]

LACRT
Нинди таксонда бар H. sapiens[d][1]
Кодлаучы ген LACRT[d][1]
Молекуляр функция laminin-1 binding[d][2], fibronectin binding[d][2], growth factor activity[d][3], collagen binding[d][2], protein N-terminus binding[d][3] һәм связывание с белками плазмы[d][2]
Күзәнәк компоненты күзәнәк тышындагы өлкә[d][4][5], secretory granule[d][6], күзәнәк тышындагы мохит[d][7][8], күзәнәк тышындагы өлкә[d][9][10][11], күзәнәк тышындагы мохит[d][12][13] һәм secretory granule[d][2][11]
Биологик процесс positive regulation of peptidyl-tyrosine phosphorylation[d][2], calcineurin-NFAT signaling cascade[d][14], positive regulation of release of sequestered calcium ion into cytosol[d][14], calcium-mediated signaling[d][15][6], positive regulation of epithelial cell proliferation[d][14], protein localization to Golgi apparatus[d][14], epithelial structure maintenance[d][16], protein acetylation[d][17], позитивная регуляция пролиферации клеток[d][4][6][18], positive regulation of epithelial cell proliferation involved in wound healing[d][19], positive regulation of macroautophagy[d][17], негативная регуляция апоптоза[d][20], слезотечение[d][21][9][22][…], negative regulation of lipopolysaccharide-mediated signaling pathway[d][20], positive regulation of secretion[d][4][6], positive regulation of calcium-mediated signaling[d][19], defense response to bacterium[d][23], regulation of signaling receptor activity[d][9], позитивная регуляция пролиферации клеток[d][9][2][3][…], calcium-mediated signaling[d][2][14][11], positive regulation of secretion[d][9][2][11] һәм positive regulation of calcineurin-NFAT signaling cascade[d][14]

Искәрмәләр

үзгәртү
  1. ↑ 1,0 1,1 UniProt
  2. ↑ 2,0 2,1 2,2 2,3 2,4 2,5 2,6 2,7 2,8 R Kumar, V Trinkaus-Randall cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland // Journal of Molecular Biology / P. Wright — Elsevier BV, 2001. — ISSN 0022-2836; 1089-8638 — doi:10.1006/JMBI.2001.4748 — PMID:11419941
  3. ↑ 3,0 3,1 3,2 Ma P., Beck S. L., Raab R. W. et al. Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin // J. Cell Biol. / J. Nunnari — Rockefeller University Press, 2006. — ISSN 0021-9525; 1540-8140 — doi:10.1083/JCB.200511134 — PMID:16982797
  4. ↑ 4,0 4,1 4,2 GOA
  5. ↑ T Nakajima, Walkup R. D., A Tochigi et al. Establishment of an appropriate animal model for lacritin studies: cloning and characterization of lacritin in monkey eyes // Experimental Eye Research — Elsevier BV, 2007. — ISSN 0014-4835; 1096-0007 — doi:10.1016/J.EXER.2007.07.019 — PMID:17850790
  6. ↑ 6,0 6,1 6,2 6,3 R Kumar, V Trinkaus-Randall cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland // Journal of Molecular Biology / P. Wright — Elsevier BV, 2001. — ISSN 0022-2836; 1089-8638 — doi:10.1006/JMBI.2001.4748 — PMID:11419941
  7. ↑ Pieragostino D., Agnifili L., Fasanella V. et al. Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy // Mol. Biosyst. — RSC, 2013. — ISSN 1742-206X; 1742-2051; 2515-4184 — doi:10.1039/C3MB25463A — PMID:23580065
  8. ↑ Böhm D., Keller K., Pieter J. et al. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach // Oncol. Rep. / D. Spandidos — Elsevier BV, 2012. — ISSN 1021-335X; 1791-2431 — doi:10.3892/OR.2012.1849 — PMID:22664934
  9. ↑ 9,0 9,1 9,2 9,3 9,4 GOA
  10. ↑ T Nakajima, Walkup R. D., A Tochigi et al. Establishment of an appropriate animal model for lacritin studies: cloning and characterization of lacritin in monkey eyes // Experimental Eye Research — Elsevier BV, 2007. — ISSN 0014-4835; 1096-0007 — doi:10.1016/J.EXER.2007.07.019 — PMID:17850790
  11. ↑ 11,0 11,1 11,2 11,3 Livstone M. S., Thomas P. D., Lewis S. E. et al. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium // Brief. Bioinform. — OUP, 2011. — ISSN 1467-5463; 1477-4054 — doi:10.1093/BIB/BBR042 — PMID:21873635
  12. ↑ Pieragostino D., Agnifili L., Fasanella V. et al. Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy // Mol. Biosyst. — RSC, 2013. — ISSN 1742-206X; 1742-2051; 2515-4184 — doi:10.1039/C3MB25463A — PMID:23580065
  13. ↑ Böhm D., Keller K., Pieter J. et al. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach // Oncol. Rep. / D. Spandidos — Elsevier BV, 2012. — ISSN 1021-335X; 1791-2431 — doi:10.3892/OR.2012.1849 — PMID:22664934
  14. ↑ 14,0 14,1 14,2 14,3 14,4 14,5 Wang J., Wang N., Xie J. et al. Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways // J. Cell Biol. / J. Nunnari — Rockefeller University Press, 2006. — ISSN 0021-9525; 1540-8140 — doi:10.1083/JCB.200605140 — PMID:16923831
  15. ↑ Wang J., Wang N., Xie J. et al. Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways // J. Cell Biol. / J. Nunnari — Rockefeller University Press, 2006. — ISSN 0021-9525; 1540-8140 — doi:10.1083/JCB.200605140 — PMID:16923831
  16. ↑ Vijmasi T., Feeling Y T Chen, Balasubbu S. et al. Topical administration of lacritin is a novel therapy for aqueous-deficient dry eye disease // Investigative Ophthalmology & Visual Science — Cadmus Press, 2014. — ISSN 0146-0404; 1552-5783 — doi:10.1167/IOVS.14-13924 — PMID:25034600
  17. ↑ 17,0 17,1 Talla V. Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolism // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2013. — 16 p. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M112.436584 — PMID:23640897
  18. ↑ Ma P., Beck S. L., Raab R. W. et al. Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin // J. Cell Biol. / J. Nunnari — Rockefeller University Press, 2006. — ISSN 0021-9525; 1540-8140 — doi:10.1083/JCB.200511134 — PMID:16982797
  19. ↑ 19,0 19,1 Hamm-Alvarez S. F. Lacritin-mediated regeneration of the corneal epithelia by protein polymer nanoparticles // J. Mater. Chem. B — RSC, 2014. — ISSN 2050-750X; 2050-7518 — doi:10.1039/C4TB00979G — PMID:25530855
  20. ↑ 20,0 20,1 Vantaku V. R., Gupta G., Rapalli K. C. et al. Lacritin Salvages Human Corneal Epithelial Cells from Lipopolysaccharide Induced Cell Death // Sci. Rep. — Macmillan Publishers, NPG, 2015. — ISSN 2045-2322 — doi:10.1038/SREP18362 — PMID:26670139
  21. ↑ McKown R. L., Wang N., Raab R. W. et al. Lacritin and other new proteins of the lacrimal functional unit // Experimental Eye Research — Elsevier BV, 2008. — ISSN 0014-4835; 1096-0007 — doi:10.1016/J.EXER.2008.09.002 — PMID:18840430
  22. ↑ Hamm-Alvarez S. F. A thermo-responsive protein treatment for dry eyes // J. Control. Release — Elsevier BV, 2014. — ISSN 0168-3659; 1873-4995 — doi:10.1016/J.JCONREL.2014.11.016 — PMID:25481446
  23. ↑ McKown R. L., Erin V Coleman Frazier, Zadrozny K. K. et al. A cleavage-potentiated fragment of tear lacritin is bactericidal // J. Biol. Chem. / L. M. Gierasch — Baltimore [etc.]: American Society for Biochemistry and Molecular Biology, 2014. — ISSN 0021-9258; 1083-351X; 1067-8816 — doi:10.1074/JBC.M114.570143 — PMID:24942736
  24. ↑ HUGO Gene Nomenclature Commitee, HGNC:29223 (ингл.). әлеге чыганактан 2015-10-25 архивланды. 18 сентябрь, 2017 тикшерелгән.
  25. ↑ UniProt, Q9ULJ7 (ингл.). 18 сентябрь, 2017 тикшерелгән.

Чыганаклар

үзгәртү
  • Степанов В.М. (2005). Молекулярная биология. Структура и функция белков. Москва: Наука. ISBN 5-211-04971-3.(рус.)
  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter (2002). Molecular Biology of the Cell (вид. 4th). Garland. ISBN 0815332181.(ингл.)


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